Characteristics of lingual papillae in diabetic rats

Basit Öğe Kaydı
dc.authorid0000-0002-6813-8351
dc.contributor.authorOrtuğ, Gürsel
dc.contributor.authorİ?nak, Seyda
dc.contributor.authorOrtuğ, Alpen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:53Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:53Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractDiabetes mellitus (DM) is a metabolic disorder resulting with many different complications including soft tissue abnormalities in the oral cavity such as periodontitis and salivary and taste dysfunction. Previous studies also reported fungal and bacterial infections in oral cavity in these patients. This study aims to represent three dimentional morphologic ultrastructural changes of the diabetic rat tongue via scanning electron microscopy. Twenty-four (24) adult male Spraque-Dawley rats, (weight ranging between 200–250 g) included in the study were randomly assigned into two groups: control rats were injected with intraperitoneally saline alone, experimental diabetes group received streptozotocin (STZ) (80 mg/kg) administrated intraperitoneally. On month four, by the end of experimental period, all animals of each group were anesthetised. All tongues were dissected totally, postfixed in 2% osmium tetroxide and then dried by critical point drying before SEM analysis. Finally, superficial epithelial configurations of the lingual papillae in experimental diabetic rats were examined by scanning electron microscopy. Diabetes mellitus caused thickness, hyperceratosis and different epithelial changes, We observed yeast-like structures and bacterial colonisations on the papillar and epithelial structure of the tongue. The morphological atrophic changes of lingual mucosa and the median rhomboid glossitis (which is primary finding of candidal infection) are characteristic observations on the lingual mucosa of the streptozotocin treated rats.
dc.identifier.citationOrtuğ, G., İ?nak, S. ve Ortuğ, A. (2018). Characteristics of lingual papillae in diabetic rats. Morphologie, 102(339), 250-254. https://dx.doi.org/10.1016/j.morpho.2018.08.003
dc.identifier.doi10.1016/j.morpho.2018.08.003
dc.identifier.endpage254
dc.identifier.issn1286-0115
dc.identifier.issue339
dc.identifier.scopusqualityQ2
dc.identifier.startpage250
dc.identifier.urihttps://hdl.handle.net/20.500.12511/981
dc.identifier.urihttps://dx.doi.org/10.1016/j.morpho.2018.08.003
dc.identifier.volume102
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Masson SAS
dc.relation.ispartofMorphologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDiabetes Mellitus
dc.subjectLingual Papillae
dc.subjectScanning Electron Microscopy
dc.titleCharacteristics of lingual papillae in diabetic rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Ortug-Alpen-2018.pdf
Boyut:
1.91 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu