Atrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope

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dc.authorid0000-0001-9919-8392
dc.authorid0000-0001-6182-5055
dc.authorid0000-0003-4856-0974
dc.authorid0000-0001-6643-9364
dc.contributor.authorParlatan, Uğur
dc.contributor.authorParlatan, Şeyma
dc.contributor.authorŞen, Kübra
dc.contributor.authorKeçoğlu, İbrahim
dc.contributor.authorUlukan, Mustafa Özer
dc.contributor.authorKarakaya, Atalay
dc.contributor.authorErkanlı, Korhan
dc.contributor.authorTürkoğlu, Halil
dc.contributor.authorUğurlucan, Murat
dc.contributor.authorÜnlü, Mehmet Burçin
dc.contributor.authorTanören, Bükem
dc.contributor.authorKarakaya, Atalay
dc.date.accessioned2022-04-29T05:59:00Z
dc.date.available2022-04-29T05:59:00Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractAtrial fibrillation (AF) is diagnosed with the electrocardiogram, which is the gold standard in clinics. However, sufficient arrhythmia monitoring takes a long time, and many of the tests are made in only a few seconds, which can lead arrhythmia to be missed. Here, we propose a combined method to detect the effects of AF on atrial tissue. We characterize tissues obtained from patients with or without AF by scanning acoustic microscopy (SAM) and by Raman spectroscopy (RS) to construct a mechano-chemical profile. We classify the Raman spectral measurements of the tissue samples with an unsupervised clustering method, k-means and compare their chemical properties. Besides, we utilize scanning acoustic microscopy to compare and determine differences in acoustic impedance maps of the groups. We compared the clinical outcomes with our findings using a neural network classification for Raman measurements and ANOVA for SAM measurements. Consequently, we show that the stiffness profiles of the tissues, corresponding to the patients with chronic AF, without AF or who experienced postoperative AF, are in agreement with the lipid-collagen profiles obtained by the Raman spectral characterization.
dc.description.sponsorshipTurkiye Cumhuriyeti Kalkinma Bakanligien_US
dc.identifier.citationParlatan, U., Parlatan, Ş., Şen, K., Keçoğlu, İ., Ulukan, M. Ö., Karakaya, A. ... Karakaya, A. (2022). Atrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-10380-z
dc.identifier.doi10.1038/s41598-022-10380-z
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid35440791
dc.identifier.scopus2-s2.0-85128435508
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-022-10380-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9389
dc.identifier.volume12
dc.identifier.wos000783915800041en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUlukan, Mustafa Özer
dc.institutionauthorKarakaya, Atalay
dc.institutionauthorErkanlı, Korhan
dc.institutionauthorTürkoğlu, Halil
dc.institutionauthorUğurlucan, Murat
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectMicro-Raman Spectroscopy
dc.subjectMicroscope
dc.subjectAtrial Fibrillation
dc.titleAtrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope
dc.typeArticle

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