Effects of whey Protein, Omega-3 Fatty Acid and Roux-En-Y gastric bypass on body weight, biochemical parameters and organ functions in an obese rat model: Experimental research

Basit Öğe Kaydı
dc.authorid0000-0002-5625-3387
dc.authorid0000-0001-7046-9515
dc.authorid0000-0003-0428-2511
dc.authorid0000-0001-9416-7757
dc.contributor.authorMert Biberoğlu, Fatma
dc.contributor.authorErdem, Nihal Zekiye
dc.contributor.authorÖzdenkaya, Yaşar
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorSaka, Burcu
dc.date.accessioned2023-05-31T09:16:53Z
dc.date.available2023-05-31T09:16:53Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Beslenme ve Diyetetik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)
dc.description.abstractPurpose: Extreme obesity (EO) is one of the biggest public health problems in the world and has grown considerably over the years. The aim of the study is to examine the effect of Roux-en-Y gastric bypass (RYGB), whey protein (WP), and omega-3 polyunsaturated fatty acid (PUFA) supplementation applied to EO rats on weight loss, histopathological changes in internal organs and biochemical alterations. Materials and Methods: Wistar albino female rats (n = 28) were used in the study and randomly divided into four groups. All rats were made obese by adding high fructose corn syrup (HFCS) to their drinking water. After the EO, WP and omega-3 PUFA supplementation was given and RYGB process was applied. At the end of the study, glucose, total cholesterol, HDL, VLDL, AST, ALT and uric acid changes and liver, kidney and pancreatic tissues were evaluated histopathologically. Results: WP and omega-3 PUFA supplementation decreased body weight (p > 0.05). Omega-3 PUFA and RYGB caused a decrease in total cholesterol (p < 0.05), WP decreased HDL (p < 0.05), WP and omega-3 PUFA caused an increase in ALT (p < 0.05). WP has been shown to have greater curative effects in rat liver and kidney tissues. It has been determined that RYGB causes necrosis in the liver and HFCS causes inflammation in the kidney. Conclusion: In the study; the positive effects of WP, omega-3 PUFA and bariatric surgery on obesity and dyslipidemia have been demonstrated. With this result, it was determined that WP, omega-3 PUFA supplementation and bariatric surgery were not superior to each other. Graphical abstract: [Figure not available: see fulltext.]
dc.identifier.citationMert Biberoğlu, F., Erdem, N. Z., Özdenkaya, Y., Özdemir, E. M. ve Saka, B. (2023). Effects of whey Protein, Omega-3 Fatty Acid and Roux-En-Y gastric bypass on body weight, biochemical parameters and organ functions in an obese rat model: Experimental research. Obesity Surgery, 33(5), 1553-1563. https://doi.org/10.1007/s11695-023-06560-z
dc.identifier.doi10.1007/s11695-023-06560-z
dc.identifier.endpage1563
dc.identifier.issn0960-8923
dc.identifier.issn1708-0428
dc.identifier.issue5
dc.identifier.pmid36971930
dc.identifier.scopus2-s2.0-85150949050
dc.identifier.scopusqualityQ1
dc.identifier.startpage1553
dc.identifier.urihttps://doi.org/10.1007/s11695-023-06560-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11001
dc.identifier.volume33
dc.identifier.wos000960207000001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMert Biberoğlu, Fatma
dc.institutionauthorErdem, Nihal Zekiye
dc.institutionauthorÖzdenkaya, Yaşar
dc.institutionauthorÖzdemir, Ekrem Musa
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofObesity Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectExtreme Obesity
dc.subjectOmega-3 PUFA
dc.subjectRoux-En-Y Gastric Bypass
dc.subjectWhey Protein
dc.titleEffects of whey Protein, Omega-3 Fatty Acid and Roux-En-Y gastric bypass on body weight, biochemical parameters and organ functions in an obese rat model: Experimental research
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Sağlık Bilimleri Enstitüsü Diğer Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Daha fazla yükle