Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model

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dc.authorid0000-0002-4899-9146
dc.contributor.authorÖkten, Sabri Berkem
dc.contributor.authorÇetin, Çağlar
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorTaha, Sevde Havva
dc.contributor.authorÖzcan, Pınar
dc.contributor.authorFıçıcıoğlu, Cem
dc.date.accessioned2023-06-01T07:44:10Z
dc.date.available2023-06-01T07:44:10Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractResearch question: Can cannabidiol (CBD) be used in the treatment of endometriosis for its anti-inflammatory, antioxidative and antiangiogenic effects? Design: Endometrial implants were surgically induced in 36 female Wistar albino rats. After confirmation of endometriotic foci, the rats were randomized into four groups. In the leuprolide acetate group, rats were given a single 1 mg/kg s.c. leuprolide acetate injection. The other groups were 5 mg/kg CBD (CBD5), saline solution and 20 mg/kg CBD (CBD20); daily i.p. injections were administered for 7 days. After 21 days, the rats were euthanised, and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-a) measurements in blood and peritoneal fluid samples, and immunohistochemical staining for TNF-a, IL-6 and vascular endothelial growth factor (VEGF) of endometriotic tissues were evaluated. Results: Significant reductions in the endometriotic implant surface area (P = 0.0213), serum TOS (P = 0.0491), OSI (P = 0.0056), IL-6 (P = 0.0236), TNF-a (P = 0.0083) and peritoneal fluid OSI (P = 0.0401), IL-6 (P = 0.0205) and TNF-a (P = 0.0045) concentrations were observed in the CBD5 group when compared with the saline solution group. Compared with the saline solution group, increased TAS concentrations in serum (P = 0.0012) and peritoneal fluid (P = 0.0145) were found in the CBD5 group. The CBD5 and leuprolide acetate groups were similar regarding inflammatory and oxidative stress parameters of serum and peritoneal fluid samples. The CBD5 group showed significantly lower mean intensity in both surface epithelium and stromal cells for VEGF (both P = 0.002) and only in surface epithelium cells for IL-6 (P = 0.0108), when compared with the leuprolide acetate group. Conclusion: Due to its anti-inflammatory, antioxidative and antiangiogenic effects, CBD might be a therapeutic agent candidate for endometriosis.
dc.description.sponsorshipDepartment of Biostatistics ; Reakiro Company ; Bezmialem Vakif Universityen_US
dc.identifier.citationÖkten, S. B., Çetin, Ç., Tok, O. E., Güler, E. M., Taha, S. H., Özcan, P. ... Fıçıcıoğlu, C. (2023). Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model. Reproductive BioMedicine Online, 46(5), 865-875. https://doi.org/10.1016/j.rbmo.2023.01.018
dc.identifier.doi10.1016/j.rbmo.2023.01.018
dc.identifier.endpage875
dc.identifier.issn1472-6483
dc.identifier.issn1472-6491
dc.identifier.issue5
dc.identifier.pmid36997400
dc.identifier.scopus2-s2.0-85151274360
dc.identifier.scopusqualityQ1
dc.identifier.startpage865
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2023.01.018
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11007
dc.identifier.volume46
dc.identifier.wos000992305600001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTok, Olgu Enis
dc.language.isoen
dc.publisherElsevier Science Ltd
dc.relation.ispartofReproductive BioMedicine Onlineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAngiogenesis
dc.subjectCannabidiol
dc.subjectEndometriosis Treatment
dc.subjectInflammation
dc.subjectOxidative Stress
dc.subjectPhytocannabinoids
dc.titleCannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model
dc.typeArticle

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