Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos

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dc.authorid0000-0003-0804-1475
dc.authorid0000-0002-0675-1839
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:51Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000427566900006
dc.descriptionPubMed ID: 29360218
dc.description.abstractMethylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure under sublethal doses are still unknown and the number of related studies is limited. Our aim was to evaluate the effects of MP on the development of zebrafish embryos focusing on development, locomotor activity, oxidant-antioxidant status, apoptosis, and ccnd1 and myca expressions. The expressions of ccnd1 and myca were determined by RT-PCR. Lipid peroxidation (LPO), nitric oxide (NO), and glutathione-S-transferase (GST) activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Locomotor activity was measured using touch-evoked movement test. MP exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group. Our findings will lead to further understanding of the mechanism of MP toxicity, and merit further research.
dc.description.sponsorshipMarmaraUniversity Scientific Research and Project Commision [SAG-E-120314-0056]en_US
dc.description.sponsorshipThis project was supported by MarmaraUniversity Scientific Research and Project Commision, Project No: SAG-E-120314-0056. Our special thanks are for the Vice Rector of Marmara University Prof. Dr. Mehmet Akalin and his team in the Department of Textile Engineering as it would have been impossible to carry out these long-term research projects without their support.en_US
dc.identifier.citationAteş, P., Ünal, İ., Üstündağ, Ü. V., Alturfan, A. A., Yiğitbaşı, T. ve Emekli Alturfan, E. (2018). Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos. Journal of Biochemical and Molecular Toxicology, 32(3). https://dx.doi.org/10.1002/jbt.22036
dc.identifier.doi10.1002/jbt.22036
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.22036
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2089
dc.identifier.volume32
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApoptosis
dc.subjectCcnd1
dc.subjectMethylparaben
dc.subjectMyca
dc.subjectOxidant Antioxidant Status
dc.titleMethylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos
dc.typeArticle

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