The therapeutic role of lamotrigine and topiramate in a depressive patient with anxiety symptoms and cognitive decline: Neurometabolic correlates

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dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-9704-6173
dc.authorid0000-0002-9704-6173
dc.authorid0000-0003-0334-811X
dc.contributor.authorHano?lu, Lütfü
dc.contributor.authorYulu?, Burak
dc.contributor.authorÇakır, Tansel
dc.contributor.authorSoğukkanlı, Kübra
dc.contributor.authorDüz Arıcı, Özge
dc.contributor.authorAtasever, Tamer
dc.date.accessioned2020-08-10T13:59:50Z
dc.date.available2020-08-10T13:59:50Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground: Lamotrigine and topiramate are well-known agents with their antiepileptic and mood stabilizing effects. Their therapeutic effect is associated with significant alteration of brain metabolism. In our study, we aimed to investigate the neurometabolic correlates of the therapeutic effects of both agents in a depressive patient with anxiety symptoms and cognitive decline. Methods: In addition to structural Cranial Magnetic Resonance Imaging, we also have performed Neuropsychometric evaluation and FDG-PET Brain fludeoxyglucose positron emission tomography (F18) (FDG PET-CT) FDG-PET before and after the treatment. Brain fludeoxyglucose positron emission tomography (F18) (FDG PET-CT) images were taken before and after the treatment using Philips Gemini TF PET/CT equipped with 16 slice CT. The raw FDG-PET data was processed using NeuroQ software (Version 3,5. Syntermed, Inc Atlanta. USA). Results: Topiramate and lamotrigine additively reduced the neuropsychiatric symptoms and test scores which were associated with the improvement of cerebral glucose metabolism. Conclusion: Our present findings support that the therapeutic effect of lamotrigine and topiramate involves a modulatory effect on the glucose metabolism in cortico-subcortical network and suggests the functional role of a bi-directional hippocampal-cingulate connectivity.
dc.identifier.citationHano?lu, L., Yulu?, B., Çakır, T., Soğukkanlı, K., Düz Arıcı, Ö. ve Atasever, T. (2016). The therapeutic role of lamotrigine and topiramate in a depressive patient with anxiety symptoms and cognitive decline: Neurometabolic correlates. Current Clinical Pharmacology, 11(4), 282-285. https://dx.doi.org/10.2174/1574884711666160905094059
dc.identifier.doi10.2174/1574884711666160905094059
dc.identifier.endpage285
dc.identifier.issn1574-8847
dc.identifier.issn2212-3938
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage282
dc.identifier.urihttps://dx.doi.org/10.2174/1574884711666160905094059
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5682
dc.identifier.volume11
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science
dc.relation.ispartofCurrent Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTherapeutic
dc.subjectDepressive
dc.subjectSymptoms
dc.titleThe therapeutic role of lamotrigine and topiramate in a depressive patient with anxiety symptoms and cognitive decline: Neurometabolic correlates
dc.typeArticle

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