Hedgehog signaling: Linking embryonic lung development and asthmatic airway remodeling

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dc.authorid0000-0001-7635-9624
dc.contributor.authorZeng, Ling-Hui
dc.contributor.authorBarkat, Muhammad Qasim
dc.contributor.authorSyed, Shahzada Khurram
dc.contributor.authorShah, Shahid
dc.contributor.authorAbbas, Ghulam
dc.contributor.authorXu, Chengyun
dc.contributor.authorMahdy, Amina
dc.contributor.authorHussain, Nadia
dc.contributor.authorHussain, Liaqat
dc.contributor.authorMajeed, Abdul
dc.contributor.authorKhan, Kashif-ur-Rehman
dc.contributor.authorWu, Ximei
dc.contributor.authorHussain, Musaddique
dc.date.accessioned2022-06-24T07:55:04Z
dc.date.available2022-06-24T07:55:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractThe development of the embryonic lung demands complex endodermal-mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during several morphogenic mechanisms, such as cell growth, differentiation, migration, and persistence of cells. On the other hand, abnormal expression or loss of regulation of Hh signaling leads to airway asthmatic remodeling, which is characterized by cellular matrix modification in the respiratory system, goblet cell hyperplasia, deposition of collagen, epithelial cell apoptosis, proliferation, and activation of fibroblasts. Hh also targets some of the pathogens and seems to have a significant function in tissue repairment and immune-related disorders. Similarly, aberrant Hh signaling expression is critically associated with the etiology of a variety of other airway lung diseases, mainly, bronchial or tissue fibrosis, lung cancer, and pulmonary arterial hypertension, suggesting that controlled regulation of Hh signaling is crucial to retain healthy lung functioning. Moreover, shreds of evidence imply that the Hh signaling pathway links to lung organogenesis and asthmatic airway remodeling. Here, we compiled all up-to-date investigations linked with the role of Hh signaling in the development of lungs as well as the attribution of Hh signaling in impairment of lung expansion, airway remodeling, and immune response. In addition, we included all current investigational and therapeutic approaches to treat airway asthmatic remodeling and immune system pathway diseases.
dc.description.sponsorshipNational Natural Science Foundation of China (NSFC)en_US
dc.identifier.citationZeng, L., Barkat, M. Q., Syed, S. K., Shah, S., Abbas, G., Xu, C. ... Hussain, M. (2022). Hedgehog signaling: Linking embryonic lung development and asthmatic airway remodeling. Cells, 11(11). http://doi.org/10.3390/cells11111774
dc.identifier.doi10.3390/cells11111774
dc.identifier.issn2073-4409
dc.identifier.issue11
dc.identifier.pmid35681469
dc.identifier.scopus2-s2.0-85130857094
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://doi.org/10.3390/cells11111774
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9537
dc.identifier.volume11
dc.identifier.wos000809169100001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMahdy, Amina
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofCellsen_US
dc.relation.publicationcategoryDiÄŸer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHedgehog Signaling
dc.subjectLung Development
dc.subjectAsthmatic Airway Remodeling
dc.subjectTargets Pathogen
dc.subjectRepairment in Tissue and Immune System
dc.titleHedgehog signaling: Linking embryonic lung development and asthmatic airway remodeling
dc.typeReview Article

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