Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies

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dc.contributor.authorŞener, Nesrin
dc.contributor.authorÖzkınalı, Sevil
dc.contributor.authorÇelik Altunoğlu, Yasemin
dc.contributor.authorYerlikaya, Şerife
dc.contributor.authorGökçe, Halil
dc.contributor.authorZurnacı, Merve
dc.contributor.authorGür, Mahmut
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorŞener, İzzet
dc.date.accessioned2021-08-02T09:26:56Z
dc.date.available2021-08-02T09:26:56Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.description.abstractNew pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the compounds was performed by spectroscopic techniques, including IR, UV-Vis, H-1-NMR and C-13-NMR. Biological activity of the compounds was evaluated by analyzing DNA protection, antimicrobial and anticancer properties. Compound 4 was effective for Salmonella typhimurium with the MIC concentration of 62.5 mu g/mL. Moreover, this compound had the highest protection activity on DNA. Cytotoxic activity of compound 4 was determined on the HeLa cancer cell line with the IC50 concentration of 976.6 mu M. The anti-cancer characteristic of compounds 4 and 5 for HeLa cancer was theoretically analyzed by molecular docking study as well. Among the tested compounds, compound 4 possessed significant results due to its in vitro cytotoxic properties. Therefore, it may be considered as a potential bioactive agent for cancer treatment studies. In addition, further in vivo analysis can be performed to indicate its anticancer property.
dc.description.sponsorshipScientific Research Projects Council of Kastamonu Universityen_US
dc.identifier.citationŞener, N., Özkınalı, S., Çelik Altunoğlu, Y., Yerlikaya, Ş., Gökçe, H., Zurnacı, M. ... Şener, İ. (2021). Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies. Journal of Molecular Structure, 1241. https://dx.doi.org/10.1016/j.molstruc.2021.130520
dc.identifier.doi10.1016/j.molstruc.2021.130520
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.molstruc.2021.130520
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7643
dc.identifier.volume1241
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntimicrobial Activity
dc.subjectAzo-Imine
dc.subjectCytotoxic Activity
dc.subjectDNA Protection
dc.subjectMolecular Docking
dc.subjectPyrazole
dc.subjectSchiff Bases
dc.titleAntiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies
dc.typeArticle

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