Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorDe Pandis, Maria Francesca
dc.contributor.authorFerri, Raffaele
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorRizzo, Marco
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorSalvetti, Marco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorOnofri, Marco
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorAarsland, Dag
dc.contributor.authorParnetti, Lucilla
dc.contributor.authorFarotti, Lucia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorDe Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorTaylor, John Paul
dc.contributor.authorMcKeith, Ian
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorHampel, Harald
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorBonanni, Laura
dc.contributor.authorBabiloni, Claudio
dc.date.accessioned2020-11-13T07:22:48Z
dc.date.available2020-11-13T07:22:48Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms.Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources.Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB ``controls", the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005).Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients.Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.
dc.description.sponsorshipMinistry of Health, Italy; H2020 Marie S. Curie ITN-ETN project; H2020-TWINN-2015 projecten_US
dc.identifier.citationPascarelli, M. T., Del Percio, C., De Pandis, M. F., Ferri, R., Lizio, R., Noce, G. ... Babiloni, C. (2020). Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. Clinical Neurophysiology, 131(11), 2716-2731. https://dx.doi.org/10.1016/j.clinph.2020.09.004
dc.identifier.doi10.1016/j.clinph.2020.09.004
dc.identifier.endpage2731
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.issue11
dc.identifier.scopusqualityQ1
dc.identifier.startpage2716
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinph.2020.09.004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6027
dc.identifier.volume131
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofClinical Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectProdromal and Overt Dementia With Lewy Bodies (DLB)
dc.subjectMild Cognitive Impairment (MCI)
dc.subjectResting State Electroencephalographic (EEG) Rhythms
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta)
dc.subjectVisual Hallucinations
dc.subjectRapid Eye Movement Sleep Behavior Disorders (RBD)
dc.titleAbnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms
dc.typeArticle

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