Factors related to follicular oxidative stress in intracytoplasmic sperm injection cycles and its effects on granulosa cells

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dc.authorid0000-0003-3302-5004
dc.authorid0000-0003-2923-5869
dc.authorid0000-0002-7059-1884
dc.contributor.authorKarabulut, Seda
dc.contributor.authorKorkmaz, Oya
dc.contributor.authorKutlu, Pelin
dc.contributor.authorKeskin, İlknur
dc.date.accessioned2021-05-27T07:39:19Z
dc.date.available2021-05-27T07:39:19Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the present study was to investigate several common conditions that may potentially be correlated with follicular oxidative status during an intracytoplasmic sperm injection (ICSI) cycle and that include the serum oestrogen level on the day of oocyte pick-up, maternal age and pregnancy outcome. Patients that were enrolled in the study were classified randomly into three groups using their numerical order. The first group were classified based on maternal age (<35 and >= 35 years) (n = 398), the second group on the serum oestradiol (E2) level on the day of human chorionic gonadotropin (hCG) administration (levels >90th percentile and <= 90th percentile) (n = 491) and the third group on pregnancy outcome (positive/negative) (n = 376). The groups were matched for the other variables (stimulation protocol, dose of gonadotropin, duration of stimulation, antral follicle count, body mass index, basal follicle stimulating hormone (FSH), and E2 levels and day of hCG trigger) to prevent the possible contribution of those parameters to the results. Each group was matched for other variables (stimulation protocol, dose of gonadotrophin, duration of stimulation, antral follicle count, body mass index, basal FSH and E2 levels and day of hCG trigger) that may have affected the outcome, except for the parameter under investigation. Maternal age (P = 0.044,168 r = 0.418), oestrogen level on day of hCG administration (P = 0.001, r = 0.436) and pregnancy outcome (AUC = 0.65, P = 0.071) were found to be correlated with follicular oxidative status. The results obtained will help us to shield patients from possible situations that may cause oxidative stress and therefore adverse outcomes of an ICSI cycle.
dc.identifier.citationKarabulut, S., Korkmaz, O., Kutlu, P. ve Keskin, İ. (2021). Factors related to follicular oxidative stress in intracytoplasmic sperm injection cycles and its effects on granulosa cells. Zygote, 29(1), 59-65. https://dx.doi.org/10.1017/S0967199420000520
dc.identifier.doi10.1017/S0967199420000520
dc.identifier.endpage65
dc.identifier.issn0967-1994
dc.identifier.issn1469-8730
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage59
dc.identifier.urihttps://dx.doi.org/10.1017/S0967199420000520
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6944
dc.identifier.volume29
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge University Press
dc.relation.ispartofZygoteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA
dc.subjectFollicular Fluid
dc.subjectIntracytoplasmic Sperm Injection
dc.subjectMural Granulosa Cells
dc.subjectOxidative Stress
dc.titleFactors related to follicular oxidative stress in intracytoplasmic sperm injection cycles and its effects on granulosa cells
dc.typeArticle

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