The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

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dc.authorid0000-0002-6183-5015
dc.contributor.authorBayrak, Bertan Boran
dc.contributor.authorYılmaz, Sebahat
dc.contributor.authorHacıhasanoğlu Çakmak, Neziha
dc.contributor.authorYanardağ, Refiye
dc.date.accessioned2021-10-22T08:55:58Z
dc.date.available2021-10-22T08:55:58Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Ana Bilim Dalı
dc.description.abstractIn this study, we aimed to evaluate whether edaravone (EDA) has a protective role against valproic acid (VPA)-induced lung damage via its antioxidative activity. Male Sprague-Dawley rats were split into four groups. Control (n = 8) rats; rats given EDA (30 mg kg(-1) day(-1); n = 10); rats given only (VPA, 500 mg kg(-1) day(-1); n = 10); rats given VPA + EDA (in the same dose and time) for 7 days. EDA and VPA were applied intraperitoneally. After 8 days, lung tissues were immediately taken from the rats. In lung homogenates, reduced glutathione, total antioxidant status levels, and superoxide dismutase, glutathione peroxidase, sodium/potassium ATPase, paraoxonase1, and carbonic anhydrase activities significantly abated, whereas catalase, glutathione reductase, glutathione-S-transferase activities insignificantly decreased in the VPA-treated group. In contrast, lipid peroxidation, reactive oxygen species, and total oxidant status levels, glycoprotein and protein carbonyl contents, nitric oxide, hydroxyproline levels, and xanthine oxidase, lactate dehydrogenase, arginase, and prolidase activities significantly increased in the VPA-given group. Administration of EDA caused the reverse effects. As a consequence, EDA prevented oxidative stress-mediated lung injury via its robust antioxidant effects.
dc.identifier.citationBayrak, B. B., Yılmaz, S., Hacıhasanoğlu Çakmak, N. ve Yanardağ, R. (2021). The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters. Journal of Biochemical and Molecular Toxicology, 35(9). https://dx.doi.org/10.1002/jbt.22847
dc.identifier.doi10.1002/jbt.22847
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.22847
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8506
dc.identifier.volume35
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectN-Dipropyl Acetic Acid
dc.subjectLung Damage
dc.subjectOxidative Stress
dc.subjectSynthetic Antioxidant
dc.titleThe effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters
dc.typeArticle

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