Can high-sensitive troponin levels within the normal range predict positivity in treadmill test?

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dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorAtıcı, Adem
dc.contributor.authorSonsöz, Mehmet Rasih
dc.contributor.authorÇevik, Erdem
dc.contributor.authorOrta, Hüseyin
dc.contributor.authorDemirtakan, Zeynep Gizem
dc.contributor.authorBarman, Hasan Ali
dc.contributor.authorBulat, Zübeyir
dc.contributor.authorKaraayvaz, Ekrem Bilal
dc.contributor.authorMercano?lu, Fehmi
dc.contributor.authorZorkun, Cafer
dc.date.accessioned2023-04-17T09:46:10Z
dc.date.available2023-04-17T09:46:10Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground This study aimed to determine whether a high level of high-sensitivity troponin T (hsTnT) predicts a positive treadmill test in patients with suspected stable ischemic heart disease (SIHD). Methods In all, 366 patients with suspected SIHD were included in the study. We measured the serum hsTnT levels before the treadmill test. The treadmill test was performed according to the Bruce protocol. Results Of the 366 patients, 97 had positive treadmill tests. The hsTnT levels were significantly higher in the positive group than in the negative group. In the binary logistic regression analysis, hsTnT, pretest probability, metabolic equivalents (METs), target heart rate (THR) percentage, and Duke treadmill score (DTS) were independent predictors of a positive treadmill test [hsTnT odds ratio (OR): 2.178, P < 0.001; pretest probability OR: 1.036, P = 0.007; METs OR: 0.755, P = 0.008; THR OR: 0.773, P < 0.001; DTS OR: 2.661, P = 0.012]. In the receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) value of the model with the combined parameters of hsTnT, pretest probability, METs, THR, and DTS was statistically significant in predicting a positive treadmill test [combined model AUC: 0.945 (0.922-0.968), P < 0.001]. Conclusions In sum, high pretest hsTnT levels predicted a positive treadmill test in patients with suspected SIHD. Analysis of the hsTnT levels before the treadmill test can increase the sensitivity and specificity of the treadmill test. The methods for measuring hsTnT levels are cheap and easily accessible and can be used before the treadmill test in patients with suspected SIHD.
dc.identifier.citationYılmaz, M., Atıcı, A., Sonsöz, M. R., Çevik, E., Orta, H., Demirtakan, Z. G. ... Zorkun, C. (2023). Can high-sensitive troponin levels within the normal range predict positivity in treadmill test? Coronary Artery Disease, 34(3), 202-209. https://dx.doi.org/10.1097/MCA.0000000000001227
dc.identifier.doi10.1097/MCA.0000000000001227
dc.identifier.endpage209
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue3
dc.identifier.pmid36951749
dc.identifier.scopus2-s2.0-85151575715
dc.identifier.scopusqualityQ3
dc.identifier.startpage202
dc.identifier.urihttps://dx.doi.org/10.1097/MCA.0000000000001227
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10870
dc.identifier.volume34
dc.identifier.wos000962377000005en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHigh-Sensitivity Troponin T
dc.subjectStable Ischemic Heart Disease
dc.subjectTreadmill Test
dc.titleCan high-sensitive troponin levels within the normal range predict positivity in treadmill test?
dc.typeArticle

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