Oncologic safety of nipple-sparing mastectomy in patients with short tumor-nipple distance

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dc.authorid0000-0001-8460-9355
dc.contributor.authorBalcı, Fatih Levent
dc.contributor.authorKara, Halil
dc.contributor.authorDülgeroğlu, Onur
dc.contributor.authorUras, Cihan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:37Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:37Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground: There is a tendency to avoid nipple-sparing mastectomy (NSM) when a tumor-nipple distance (TND) is <2 cm due to the risk of occult nipple involvement. The purpose of the study was to determine whether the patients who undergo NSM with immediate reconstruction are oncologically safe when TND is <2 cm. Methods: Patients who underwent NSM followed by immediate reconstruction for breast cancer were retrospectively analyzed. Patients who are negative for nipple-base in either frozen-section or paraffin histopathology were included. MRI was used to obtain TNDs to compare local-recurrence-free and disease-free survival in group I (TND <2 cm) and group II (TND ?2 cm). Disease-free survival rates were determined to assess the outcome. Results: Of the 214 cases with malignancy on MRI, 21 cases diagnosed with pure ductal carcinoma in situ were excluded. Among the 193 NSM cases diagnosed with invasive cancer, TND was <2.0 cm in 59 (30.56%) cases and ?2.0 cm in 134 (69.43%) cases. No significant differences were found between groups in regards to ER, PR, HER2-neu status, and nodal involvement (P = 0.34, P = 0.41, P = 0.54, and P = 0.12 respectively). In a median follow-up time of 62 months (range; 13-114), patients in group I had four local recurrences, whereas group II was found to have five local and three distant metastases. No significant differences were observed between groups concerning disease-free survival (10-year DFS 93.2% vs 96.3%; P = 0.368 respectively). Conclusions: Patients who have invasive cancer diagnosis with a TND <2 cm are eligible to undergo therapeutic NSM with immediate reconstruction.
dc.identifier.citationBalcı, F. L., Kara, H., Dülgeroğlu, O. ve Uras, C. (2019). Oncologic safety of nipple-sparing mastectomy in patients with short tumor-nipple distance. Breast Journal, 25(4), 612-618. https://dx.doi.org/10.1111/tbj.13289
dc.identifier.doi10.1111/tbj.13289
dc.identifier.endpage618
dc.identifier.issn1075-122X
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage612
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1440
dc.identifier.urihttps://dx.doi.org/10.1111/tbj.13289
dc.identifier.volume25
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.relation.ispartofBreast Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast Cancer
dc.subjectMastectomy
dc.subjectNipple-Sparing Mastectomy
dc.titleOncologic safety of nipple-sparing mastectomy in patients with short tumor-nipple distance
dc.typeArticle

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