Effect of perivascular low dose ethanol on rat femoral vessels: Preliminary study

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dc.contributor.authorBaş, Soysal
dc.contributor.authorÖzakkoyunlu Hasçiçek, Seyhan
dc.contributor.authorUçak, Ramazan
dc.contributor.authorGünenç, Alican
dc.contributor.authorKarasoy Yeşilada, Ayşin
dc.date.accessioned2020-12-22T07:58:43Z
dc.date.available2020-12-22T07:58:43Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description.abstractVasospasm is one of the important causes of morbidity in free flap and replantation surgery. In secondary Raynaud’s phenomenon, nearly half of the patients experience digital ulceration, pain and loss of function at least once in their lifetime. The aim of this study is to investigate the vasodilation effect of ethanol-mediated chemical denervation on peripheral vessels by topical administration. In this study, 27 Wistar albino male rats weighing 250-300 grams were used. The rats were randomly divided into three groups: saline (group S, n = 8), lidocaine (group L, n = 9) and 96% ethanol (group E, n = 9). According to group, 0.1 mL saline, 0.1 mL lidocaine and 0.1 mL ethanol were applied around the rat femoral neurovascular bundle. After the application, on the 0th day and 3th weeks, femoral artery and vein diameters were measured. After 3. weeks, histopathological samples from femoral artery, vein and nerve were evaluated. On the 0th day, the mean diameter of the femoral artery and vein was similar in group E and L and higher than group S. After three weeks, the vasodilatation effect of ethanol was increased in group E. In Group L and S, the vasodilatation effect was lost. Histopathological examination showed that ethanol significantly caused perivascular inflammation and nerve degeneration compared to other agents and did not cause endothelial damage. Vasodilatation obtained by ethanol is a rapid onset and long-lasting effect. It is also inexpensive and effective for peripheral vasodilatation.
dc.identifier.citationBaş, S., Özakkoyunlu Hasçiçek, S., Uçak, R., Günenç, A. ve Karasoy Yeşilada, A. (2020). Effect of perivascular low dose ethanol on rat femoral vessels: Preliminary study. Journal of Plastic Surgery and Hand Surgery, 54(6), 358-364. https://dx.doi.org/10.1080/2000656X.2020.1788042
dc.identifier.doi10.1080/2000656X.2020.1788042
dc.identifier.endpage364
dc.identifier.issn2000-656X
dc.identifier.issn2000-6764
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage358
dc.identifier.urihttps://dx.doi.org/10.1080/2000656X.2020.1788042
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6127
dc.identifier.volume54
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Plastic Surgery and Hand Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEthanol
dc.subjectMicrosurgery
dc.subjectRaynaud’s Phenomenon
dc.subjectVasodilatation
dc.subjectVasospasm
dc.titleEffect of perivascular low dose ethanol on rat femoral vessels: Preliminary study
dc.typeArticle

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