Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats

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dc.authorid0000-0003-0128-6947
dc.contributor.authorÇekmez, Yasemin
dc.contributor.authorKorkmaz, Vakkaş
dc.contributor.authorÇakır, Aslı
dc.contributor.authorGöçmen, Ahmet
dc.contributor.authorErgün, Yusuf
dc.contributor.authorGülşen, Serdar
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:25Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:25Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: To investigate the abortifacient effect of metoclopramide on decidual and trophoblastic tissues with immunohistochemical investigation of galectin-1 expression in pregnant rats. STUDY DESIGN: A total of 24 pregnant rats were selected for the study and divided into 3 groups as untreated, low-dose (1 mg/kg) metoclopramide applied, and high-dose (3 mg/kg) metoclopramide applied from days 5-15 of pregnancy. All rats were laparotomized on day 19 of pregnancy, and number of implantation sites, resorption, and dead or alive fetuses were recorded for evaluating abortifacient activity. Galectin-1 expression was investigated from decidual and trophoblastic tissues via immunohistochemical staining. RESULTS: The mean percentage of abortion was detected higher in the high-dose group than both control and low-dose groups. Galectin-1 staining was more intense and universal in the untreated group than both high- and low-dose metoclopramide exposed groups in labyrinth trophoblasts and decidual tissue. CONCLUSION: Metoclopramide exposure, especially in high doses, may cause abortion, and this drug should be recommended for use during pregnancy only when the benefit outweighs the risk.
dc.identifier.citationÇekmez, Y., Korkmaz, V., Çakır, A., Göçmen, A., Ergün, Y. ve Gülşen, S. (2017). Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats. Journal of Reproductive Medicine, 62(4), 427-431.
dc.identifier.endpage431
dc.identifier.issn0024-7758
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage427
dc.identifier.urihttps://hdl.handle.net/20.500.12511/770
dc.identifier.volume62
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJournal of Reproductive Medicine, Inc.
dc.relation.ispartofJournal of Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAbnormalities
dc.subjectAbortifacient Agents
dc.subjectAbortifacients
dc.subjectAbortion
dc.subjectAntiemetics/Adverse Effects
dc.subjectDecidua
dc.subjectDrug-Induced/Epidemiology
dc.subjectFetal Death/Chemically Induced
dc.subjectGalectin-1
dc.subjectMetoclopramide
dc.subjectMetoclopramide/Adverse Effects
dc.subjectPregnancy
dc.subjectTeratogens
dc.subjectTrophoblasts
dc.titleAbortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats
dc.typeArticle

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