Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?

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dc.authorid0000-0002-0354-5108
dc.authorid0000-0003-1844-1288
dc.contributor.authorErşahan, Şeyda
dc.contributor.authorÖzçelik, Fatih
dc.contributor.authorŞirin, Dursun Ali
dc.contributor.authorErdem Hepsenoğlu, Yelda
dc.contributor.authorÖzçelik, İlbey Kayra
dc.contributor.authorTopbaş, Celalettin
dc.date.accessioned2023-10-05T10:48:56Z
dc.date.available2023-10-05T10:48:56Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalı
dc.description.abstractTo investigate the relationship between apical periodontitis [AP] severity and inflammatory markers [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-?), and Mid-Regional Pro Adrenomedullin (MR-proADM)] in patients with AP. A total of 162 subjects were divided into three categories: AP group (n = 80), periodontitis (P) group (n = 42), healthy control group (n = 40). The scoring of disease severity in 80 AP patients without any periodontal disease, using dental radiographs, was based on “The Abscess Score” (AS), as those having at least 1 tooth with AP and severity of PAI 3–4 were classified as AS 1 (mild); those with only1 tooth and severity of PAI 5 as AS 2 (moderate) and those having > 2 tooth with severity of PAI 5 as AS 3 (severe). Blood samples were collected from all of the patients. Enzyme-linked immunosorbent assay was used to evaluate the samples. The MR-pro ADM levels of both the AP and P groups were considerably higher than the control group (p < 0.01). The IL-12 levels of the AP group were higher than the P and control groups (p < 0.05). TNF-? levels of the P group were significantly higher than both the AP and control groups (p < 0.01). MR-pro ADM levels of both the AP and Periodontitis groups were higher than the control group. TNF-? was a biomarker of periodontitis, while IL-12 was a biomarker of apical periodontitis.
dc.identifier.citationErşahan, Ş., Özçelik, F., Şirin, D. A., Erdem Hepsenoğlu, Y., Özçelik, İ. K. ve Topbaş, C. (2023). Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease? Odontology, 111(3), 708-718. https://doi.org/10.1007/s10266-022-00767-9
dc.identifier.doi10.1007/s10266-022-00767-9
dc.identifier.endpage718
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.issue3
dc.identifier.pmid36414882
dc.identifier.scopus2-s2.0-85142229733
dc.identifier.scopusqualityN/A
dc.identifier.startpage708
dc.identifier.urihttps://doi.org/10.1007/s10266-022-00767-9
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11529
dc.identifier.volume111
dc.identifier.wos000886450500001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErşahan, Şeyda
dc.institutionauthorErdem Hepsenoğlu, Yelda
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofOdontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApical Periodontitis
dc.subjectChronic Periodontitis
dc.subjectIL-12
dc.subjectMid Regional Proadrenomedullin
dc.subjectTNF-?
dc.titleIs adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?
dc.typeArticle

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