High soluble CD30 levels and associated anti-HLA antibodies in patients with failed renal allografts

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dc.contributor.authorKarahan, Gonca Emel
dc.contributor.authorÇalışkan, Yaşar
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorKekik, Çiğdem
dc.contributor.authorBakkaloğlu, Hüseyin
dc.contributor.authorÇalışkan, Bahar
dc.contributor.authorTürkmen, Aydın
dc.contributor.authorSever, Mehmet Şükrü
dc.contributor.authorSavran O?uz, Fatma
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:31Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000394162200001
dc.descriptionPubMed ID: 28058698
dc.description.abstractIntroduction: Serum soluble CD30 (sCD30), a 120-kD glycoprotein that belongs to the tumor necrosis factor receptor family, has been suggested as a marker of rejection in kidney transplant patients. The aim of this study was to evaluate the relationship between sCD30 levels and anti-HLA antibodies, and to compare sCD30 levels in patients undergoing hemodialysis (HD) with and without failed renal allografts and transplant recipients with functioning grafts. Methods: 100 patients undergoing HD with failed grafts (group 1), 100 patients undergoing HD who had never undergone transplantation (group 2), and 100 kidney transplant recipients (group 3) were included in this study. Associations of serum sCD30 levels and anti-HLA antibody status were analyzed in these groups. Results: The sCD30 levels of group 1 and group 2 (154 +/- 71 U/mL and 103 +/- 55 U/mL, respectively) were significantly higher than those of the transplant recipients (group 3) (39 +/- 21 U/mL) (p<0.001 and p<0.001). The serum sCD30 levels in group 1 (154 +/- 71 U/mL) were also significantly higher than group 2 (103 +/- 55 U/mL) (p<0.001). Anti-HLA antibodies were detected in 81 (81%) and 5 (5%) of patients in groups 1 and 2, respectively (p<0.001). When multiple regression analysis was performed to predict sCD30 levels, the independent variables in group 1 were the presence of class I anti-HLA antibodies (beta = 0.295; p = 0.003) and age (beta = -0.272; p = 0.005), and serum creatinine (beta = 0.218; p = 0.027) and presence of class II anti-HLA antibodies (standardized beta = 0.194; p = 0.046) in group 3. Conclusions: Higher sCD30 levels and anti-HLA antibodies in patients undergoing HD with failed renal allografts may be related to higher inflammatory status in these patients.
dc.identifier.citationKarahan, G. E., Çalışkan, Y., Özdilli, K., Kekik, Ç., Bakkaloğlu, H., Çalışkan, B. ... Savran O?uz, F. (2016). High soluble CD30 levels and associated anti-HLA antibodies in patients with failed renal allografts. International Journal of Artificial Organs, 39(11), 547-552. https://dx.doi.org/10.5301/ijao.5000537
dc.identifier.doi10.5301/ijao.5000537
dc.identifier.endpage552
dc.identifier.issn0391-3988
dc.identifier.issn1724-6040
dc.identifier.issue11
dc.identifier.scopusqualityQ3
dc.identifier.startpage547
dc.identifier.urihttps://dx.doi.org/10.5301/ijao.5000537
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2735
dc.identifier.volume39
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd.
dc.relation.ispartofInternational Journal of Artificial Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-HLA Antibody
dc.subjectFailed Renal Allografts
dc.subjectHemodialysis
dc.subjectRenal Transplantation
dc.subjectsCD30
dc.titleHigh soluble CD30 levels and associated anti-HLA antibodies in patients with failed renal allografts
dc.typeArticle

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