Investigation of effects of low level laser therapy in distraction osteogenesis

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dc.authorid0000-0002-6705-3110
dc.contributor.authorGürler, Gökhan
dc.contributor.authorGürsoy, Bahar
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:56Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:56Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000456954700003
dc.descriptionPubMed ID: 29885471
dc.description.abstractPurpose: The purpose of the study was to investigate the histopathological effects of low level laser therapy (LLLT) application in distraction osteogenesis (DO). Materials and Methods: Twenty adult female New Zealand white rabbits were included in the study. Under general anesthesia unilateral mandibular corpus osteotomy was performed. Custom made external distractors were placed to right mandibles of rabbits. After five days of latency period, distractors were activated once a day for 5 days with 1 mm/day frequency. Animals in the study group were exposed to LLLT from six different points transcutanously after each distractor activation. Control group was not exposed to laser irradiation. Animals were sacrificed after 15 and 30 days of consolidation periods and mandibles were processed for histopathological investigation under light microscope. Bone healing was analyzed with a semi-quantitative 4 point scale. Results: Osteoblastic activity and vascularization were found higher in the study group than control group after 15 days consolidation. Chondroblastic activity of the control group was significantly higher than the study group in both 15 and 30 days of consolidation groups. Osteoblastic activity and trabecular bone formation were found significantly higher in the study group than the control group after 15 days consolidation. Conclusions: The use of LLLT in activation period of distraction osteogenesis stimulates bone repair in the early stages of distraction osteogenesis by inducing intramembranous healing and less cartilage tissue formation in the bone callus.
dc.description.sponsorshipMarmara University Scientific Research Project Commission [SAG-A-060308-0025]en_US
dc.description.sponsorshipThis research was funded by Marmara University Scientific Research Project Commission with project number 'SAG-A-060308-0025'.en_US
dc.identifier.citationGürler, G. ve Gürsoy, B. (2018). Investigation of effects of low level laser therapy in distraction osteogenesis. Journal of Stomatology Oral and Maxillofacial Surgery, 119(6), 469-476. https://dx.doi.org/10.1016/j.jormas.2018.05.006
dc.identifier.doi10.1016/j.jormas.2018.05.006
dc.identifier.endpage476
dc.identifier.issn2468-7855
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage469
dc.identifier.urihttps://dx.doi.org/10.1016/j.jormas.2018.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1827
dc.identifier.volume119
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Stomatology Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDistraction Osteogenesis
dc.subjectLow Level Laser
dc.subjectBone Healing
dc.subjectBone Augmentation
dc.titleInvestigation of effects of low level laser therapy in distraction osteogenesis
dc.typeArticle

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