Relationship between interleukin 33 and tissue factor in non-diabetic and diabetic obese patients

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dc.authorid0000-0002-8662-5284
dc.authorid0000-0002-0675-1839
dc.authorid0000-0002-5919-1986
dc.authorid0000-0002-0109-5086
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorAlagöz, Maide Hacer
dc.contributor.authorYiğit, Pakize
dc.contributor.authorEmekli, Nesrin
dc.date.accessioned2021-11-05T07:55:18Z
dc.date.available2021-11-05T07:55:18Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThe aim of the study is to investigate the relationship between tissue factor (TF) and Interleukin-33 (IL-33) and biochemical parameters in diabetic obese and non-diabetic obese patients. 21 healthy controls, 25 non-diabetic and 36 diabetic-obese patients were included in the study. While there was no difference between the groups in terms of IL-33 levels (p> 0.05), TF levels of diabetic obese group were statistically significantly higher than control group (p <0.05). HDL levels of the obese and diabetic obese groups were significantly lower than control group, and triglyceride, glucose, insulin, C-reactive protein (CRP), hemoglobin A1c (HbA1c), and HOMA-IR levels were significantly higher (p <0.05). A positive correlation was found between TF activity, and HbA1c and glucose levels (p <0.05). This suggests that TF may be predictive for diabetes which develop in the background of obesity, and that TF can be used as a prognostic value for diabetes.
dc.identifier.citationÇakıcı, Ç., Yiğitbaşı, T., Alagöz, M. H., Yiğit, P. ve Emekli, N. (2021). Relationship between interleukin 33 and tissue factor in non-diabetic and diabetic obese patients. Acta Pharmaceutica Sciencia, 59(4), 559-573. https://dx.doi.org/10.23893/1307-2080.APS.05934
dc.identifier.doi10.23893/1307-2080.APS.05934
dc.identifier.endpage573
dc.identifier.issn1307-2080
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage559
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05934
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8569
dc.identifier.volume59
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIstanbul Medipol University
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes Mellitus
dc.subjectInterleukin 33
dc.subjectObesity
dc.subjectTissue Factor
dc.titleRelationship between interleukin 33 and tissue factor in non-diabetic and diabetic obese patients
dc.typeArticle

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