Low O6-methylguanine-dna methytransferase (MGMT) and pan-cytokeratin (PAN-CK) expression via immunohistochemistry in pituitary adenomas

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dc.contributor.authorBaşaran, Recep
dc.contributor.authorÖnöz, Mustafa
dc.contributor.authorBölükbaşı, Fatih Han
dc.contributor.authorEfendioğlu, Mustafa
dc.contributor.authorSav, Aydın
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:44Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:44Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractIntroduction. Pituitary adenomas (PA) are the third most common intracranial tumors, with an incidence rate of 10-15%. More than half are invasive, infiltrating adjacent structures. The primary objective of this project was to determine whether MGMT expression is associated with the invasiveness of PA. Material and Method. All patients who underwent surgical decompression consecutively between 2007- 2012 were included. All data were obtained from the case records. Formalin-fixed paraffin-embedded (FFPE) tissue specimens were stained with hematoxylin and eosin (HE) and then examined via light microscope. Paraffin blocks that lacked necrosis and hemorrhage were chosen for histologic examination. In addition to an immunoprofile battery that consisted of Ki-67 and p53, MGMT, S-100 and Pan-CK were evaluated as well. Results. The subjects included 25 women and 15 men. The mean age was 48.9 ± 14.5 years. Of these, 63% of cases involved the invasion of adjacent structures. Of the PA, 17 (42%) were non-functioning pituitary adenomas (NFPA). There was a statistically significant relationship between the invasiveness and Ki-67, p53, MGMT expression, and prolactinoma. Gonodotropinomas were mostly non-invasive. FPAs presented invasive features more frequently than NFPAs. Pan-CK was positive in GH-secreting adenomas but negative in FSH- and LH-secreting adenomas. Conclusion. Ki-67 and p53 in lower expression level can be used for evaluating invasiveness but not for recurrence. MGMT expression can be a useful IHC indicator for invasiveness. However, Pan-CK cannot be used for invasiveness or aggressiveness.
dc.identifier.citationBaşaran, R., Önöz, M., Bölükbaşı, F. H., Efendioğlu, M. ve Sav, A. (2017). Low O6-methylguanine-dna methytransferase (MGMT) and pan-cytokeratin (PAN-CK) expression via immunohistochemistry in pituitary adenomas. Acta Endocrinologica, 13(3), 282-293. https://dx.doi.org/10.4183/aeb.2017.282
dc.identifier.doi10.4183/aeb.2017.282
dc.identifier.endpage293
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage282
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1242
dc.identifier.urihttps://dx.doi.org/10.4183/aeb.2017.282
dc.identifier.volume13
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Endocrinologica Foundation
dc.relation.ispartofActa Endocrinologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytokeratin
dc.subjectImmunohistochemistry
dc.subjectInvasiveness
dc.subjectKi-67
dc.subjectMGMT
dc.subjectP53
dc.subjectPituitary Adenoma
dc.titleLow O6-methylguanine-dna methytransferase (MGMT) and pan-cytokeratin (PAN-CK) expression via immunohistochemistry in pituitary adenomas
dc.typeArticle

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