Relation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura

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dc.authorid0000-0002-6299-7067
dc.contributor.authorAkın, Mehmet
dc.contributor.authorTurgut, Sebahat
dc.contributor.authorAyada, Ceylan
dc.contributor.authorPolat, Yusuf
dc.contributor.authorIşık Balcı, Yasemin
dc.contributor.authorErdoğan, Fırat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:04Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:04Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000296823500011
dc.descriptionPubMed ID: 21718764
dc.description.abstractThe current study was conducted to assess 3435C>T multidrug resistance 1 gene polymorphism and the efficacy of high dose methylprednisolone (HDMP) in childhood acute idiopathic thrombocytopenic purpura patients. Methods: A total of 31 childhood acute Idiopathic thrombocytopenic purpura patients (17 females, 14 males) between the ages of 2 and 16 years of age were included in the study. High-dose methylprednisolone was given at a dose of 30 mg/kg/day for 3 days and 20 mg/kg/day for 4 days, consecutively and intravenously. Polymerase chain reaction-restriction fragment length polymorphism was used for the detection of C3435T single nucleotide polymorphism. Fragments obtained were 238 bp to T/T genotype, 172 bp and 60 bp fragments to the C/C genotype, and 238 bp, 172 bp and 60 bp to the C/T genotype. Results: The distribution of CC, CT, and TT genotypes were 19.0%, 61.3%, and 19.4%, respectively. Both allele frequencies of C and T were the same -50%. There was no significant difference in genotype and allele distribution between the patients with LIP and the control group (chi(2)=0.84 p = 0.65, chi(2)=0.2 p = 0.63, respectively). There were no significant differences in age, gender, and pre- and post-treatment platelet counts between CC, CT, and TT genotypes of the MDR gene. Response to treatment shows no significant difference between genotype and allele groups. Conclusion: In our study, there was no difference in the HDMP treatment response between MDR1 gene genotypes. However, it should be noted that this study includes a small group of patients. Our data should therefore be considered preliminary, awaiting further confirmatory studies on an expanded patient base.
dc.identifier.citationAkın, M., Turgut, S., Ayada, C., Polat, Y., Işık Balcı, Y. ve Erdoğan, F. (2011). Relation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura. Gene, 487(1), 80-83. https://dx.doi.org/10.1016/j.gene.2011.06.019
dc.identifier.doi10.1016/j.gene.2011.06.019
dc.identifier.endpage83
dc.identifier.issn0378-1119
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage80
dc.identifier.urihttps://dx.doi.org/10.1016/j.gene.2011.06.019
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2559
dc.identifier.volume487
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMDR1
dc.subjectIdiopathic Thrombocytopenic Purpura
dc.subjectHigh Dose Methylprednisolone
dc.titleRelation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura
dc.typeArticle

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