A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human

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dc.authorid0000-0002-6895-8560
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorGök, Özlem
dc.contributor.authorErenberk, Ufuk
dc.contributor.authorDündaröz, Mehmet Ruşen
dc.contributor.authorTorun, Emel
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorElibol, Birsen
dc.contributor.authorUysal, Ömer
dc.contributor.authorDündar, Tolga Turan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:36Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000352138500020
dc.descriptionPubMed ID: 25785999
dc.description.abstractAging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.
dc.description.sponsorshipUniversity Research Council, Bezmialem Vakif University [BAP: 6.2013/21]en_US
dc.description.sponsorshipThis study was supported partially by a grant from the University Research Council, Bezmialem Vakif University (BAP: 6.2013/21) and partially by Ulkan Kilic, PhD, PhD. University Research Council, Bezmialem Vakif University had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript; however, Ulkan Kilic, PhD, PhD had a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.citationKılıç, Ü., Gök, Ö., Erenberk, U., Dündaröz, M. R., Torun, E., Küçükardalı, Y. ... Dündar, T. T. (2015). A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. Plos One, 10(3). https://dx.doi.org/10.1371/journal.pone.0117954
dc.identifier.doi10.1371/journal.pone.0117954
dc.identifier.issn1932-6203
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0117954
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3691
dc.identifier.volume10
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSIRT1
dc.subjectProtein
dc.subjectGene Expression
dc.titleA remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human
dc.typeArticle

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