Predictive value of systemic immune-inflammation index in determining mortality in COVID-19 patients

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dc.authorid0000-0002-5357-4273
dc.contributor.authorKaraaslan, Tahsin
dc.contributor.authorKaraaslan, Esra
dc.date.accessioned2022-09-05T06:29:37Z
dc.date.available2022-09-05T06:29:37Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: The aim of this study was to evaluate whether systemic immune-inflammation index (SD) could predict mortality in patients with novel coronavirus 2019 (COVID-19) disease. Methods: This two-center, retrospective study included a total of 191 patients with confirmed diagnosis of COVID-19 via nucleic acid test (NAT). The SII was calculated based on the complete blood parameters (neutrophil x platelet/lymphocyte) during hospitalization. The relationship between the SII and other inflammatory markers and mortality was investigated. Results: The mortality rate was 18.3%. The mean age was 54.32 +/- 17.95 years. The most common symptoms were fever (70.7%) and dry cough (61.3%), while 8 patients (4.2%) were asymptomatic. The most common comorbidities were hypertension (37.7%), diabetes (23.0%), chronic renal failure (14.7%), and heart failure (7.9%) which all significantly increased the mortality rate (p<0.001). There was a highly positive correlation between the SII and polymorphonuclear leukocyte (PNL), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) (r=0.754, p<0.001; r=0.812, p<0.001; r=0.841, p<0.001, respectively), while a moderate, positive correlation was found between the SII and C-reactive protein (CRP) (r=0.439, p<0.001). There was a significant correlation between the SII and mortality (U=1,357, p<0.001). The cut-off value of SII was 618.8 (area under the curve=0.751, p<0.001) with 80.0% sensitivity and 61.5% specificity. A cut-off value of >618.8 was associated with a 4.68-fold higher mortality. Conclusion: Similar to NLR and PLR, the SII is a proinflammatory marker of systemic inflammation and can be effectively used in independent predicting COVID-19 mortality.
dc.identifier.citationKaraaslan, T. ve Karaaslan, E. (2022). Predictive value of systemic immune-inflammation index in determining mortality in COVID-19 patients. Journal of Critical Care Medicine, 8(3), 156-164. http://doi.org/10.2478/jccm-2022-0013
dc.identifier.doi10.2478/jccm-2022-0013
dc.identifier.endpage164
dc.identifier.issn2393-1809
dc.identifier.issn2393-1817
dc.identifier.issue3
dc.identifier.pmid36062039
dc.identifier.startpage156
dc.identifier.urihttp://doi.org/10.2478/jccm-2022-0013
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9681
dc.identifier.volume8
dc.identifier.wos000842464800003en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraaslan, Esra
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofJournal of Critical Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectMortality
dc.subjectSystemic Immune-Inflammation Index
dc.subjectNeutrophil/Lymphocyte Ratio
dc.subjectInflammatory Markers
dc.titlePredictive value of systemic immune-inflammation index in determining mortality in COVID-19 patients
dc.typeArticle

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