Association of Enteric Protist Blastocystis spp. and gut microbiota with hepatic encephalopathy

Basit Öğe Kaydı
dc.authorid0000-0002-0060-2859
dc.authorid0000-0002-2752-1223
dc.contributor.authorYıldız, Sedat
dc.contributor.authorDoğan, İbrahim
dc.contributor.authorDoğruman Al, Funda
dc.contributor.authorNalbantoğlu, Ufuk
dc.contributor.authorÜstek, Duran
dc.contributor.authorSarzhanov, Fakhriddin
dc.contributor.authorYıldırım, Süleyman
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:12Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000391085100011
dc.descriptionPubMed ID: 27981305
dc.description.abstractBackground & Aims: Hepatic encephalopathy (HE) is a serious neuropsychiatric sequela emerging in the advanced stages of cirrhosis. The gut microbiota plays an important role in the development of HE. The aim of the study was to analyze the dynamic interplay between microbiota and Blastocystis in cirrhotic patients with or without encephalopathy. Methods: The study was designed as cross-sectional study. A total of 37 patients from the Ankara city, admitted to the University Hospital within a 6-month period prior to enrolment into the study were included in the study. After the regular health checks, clinical histories, clinical examinations, and Psychometric HE Score (PHES) points, patients' MELD and CTP scores were recorded. The fecal microbiota configurations were characterized by targeting hypervariable regions V3 and V4 of the 16S rRNA gene using Illumina MiSeq System. Results: Blastocystis spp. were detected in 21.6% (n = 8) of all cirrhotic patients. When those were analyzed by subgroups, four of them were subtype 2, three were subtype 3 and one was subtype 1. Blastocystis spp. were not found in any of the patients with HE; however, they were detected in 38.1% of the patients without HE. Also the increase in the bacterial diversity was observed along with the absence of Blastocystis. It was suggested that there was an inverse relationship between Blastocystis spp. and advanced stages of HE and the structure and composition of gut microbiota. Conclusion: The absence of Blastocystis spp. is associated with the HE severity and dysbiosis in the gut microbiota.
dc.description.sponsorshipScientific and Technological Research Council of Turkey, Career Reintegration Grant [TUBITAK-2232]en_US
dc.description.sponsorshipO. Ufuk Nalbantoglu was partially supported by the Scientific and Technological Research Council of Turkey, Career Reintegration Grant TUBITAK-2232.en_US
dc.identifier.citationYıldız, S., Doğan, İ., Doğruman Al, F., Nalbantoğlu, U., Üstek, D., Sarzhanov, F. ... Yıldırım, S. (2016). Association of Enteric Protist Blastocystis spp. and gut microbiota with hepatic encephalopathy. Journal Of Gastrointestınal and Liver Diseases, 25(4), 489-497. https://dx.doi.org/10.15403/jgld.2014.1121.254.yiz
dc.identifier.doi10.15403/jgld.2014.1121.254.yiz
dc.identifier.endpage497
dc.identifier.issn1841-8724
dc.identifier.issn1842-1121
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage489
dc.identifier.urihttps://dx.doi.org/10.15403/jgld.2014.1121.254.yiz
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3125
dc.identifier.volume25
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedical Univ Press
dc.relation.ispartofJournal Of Gastrointestınal and Liver Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlastocystis
dc.subjectHepatic Encephalopthy
dc.subjectMinimal Hepatic Encephalopathy
dc.subjectGut Microbiota
dc.subjectLiver Cirrhosis
dc.titleAssociation of Enteric Protist Blastocystis spp. and gut microbiota with hepatic encephalopathy
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ustek_Duran.pdf
Boyut:
614.78 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu