Mean platelet volume as an inflammation marker in active pulmonary tuberculosis

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dc.authorid0000-0001-6639-2797
dc.contributor.authorGünlüoğlu, Gülşah
dc.contributor.authorErtan Yazar, Esra
dc.contributor.authorŞimşek Veske, Nurdan
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.contributor.authorAltın, Sedat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:45Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:45Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls. In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined. Methods: This study included 82 patients with active PTB and 95 healthy subjects (control group). Whole blood counts, CRP level, and ESR were compared between the two groups. In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated. Results: The MPV was 7.74 ± 1.33/µL in the PTB group and 8.20 ± 1.13/µL in the control group (p = 0.005). The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease. Conclusions: The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. The MPV does not reflect the severity of the disease. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable.
dc.identifier.citationGünlüoğlu, G., Ertan Yazar, E., Şimşek Veske, N., Seyhan, E. C. ve Altın, S. (2014). Mean platelet volume as an inflammation marker in active pulmonary tuberculosis. Multidisciplinary Respiratory Medicine, 9(1). https://dx.doi.org/10.1186/2049-6958-9-11
dc.identifier.doi10.1186/2049-6958-9-11
dc.identifier.issn1828-695X
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1468
dc.identifier.urihttps://dx.doi.org/10.1186/2049-6958-9-11
dc.identifier.volume9
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.relation.ispartofMultidisciplinary Respiratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 2.0 Generic*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/*
dc.subjectInflammation Markers
dc.subjectMean Platelet Volume
dc.subjectPulmonary Tuberculosis
dc.titleMean platelet volume as an inflammation marker in active pulmonary tuberculosis
dc.typeArticle

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