Safety of bioabsorbable implants in vitro

Basit Öğe Kaydı
dc.authorid0000-0001-9052-4411
dc.authorid0000-0002-0022-0439
dc.authorid0000-0002-1310-068X
dc.authorid0000-0002-7794-9308
dc.contributor.authorİşyar, Mehmet
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorNusran, Gürdal
dc.contributor.authorGüler, Olcay
dc.contributor.authorYalçın, Sercan
dc.contributor.authorMahiroğulları, Mahir
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:21Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:21Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.description.abstractBackground: The aim of the present study was to investigate the safety of bioabsorbable plates and screws in humans. Methods: For this purpose, an implant system based on [poly(lactic-co-glycolic acids)(85:15)] was designed. The system was tested for pH, temperature, and swelling and then its surface morphology was analyzed for surface porosity using environmental electron microscopy. Then, the effects of this bioabsorbable system on the viability and profileration of osteocytes were examined on a molecular level via in vitro experiments. A [poly(lactic-co-glycolic acids)(90:10)] bioabsorbable implant, which is commercially available and used in orthopedic surgery, was used as control group. For the statistical evaluation of the data obtained in the present study, the groups were compared by Tukey HSD test following ANOVA. The significance level was set as p < 0.05. Results: It was observed that the osteocytes cultivated on the PLGA system designed in the present study included more live cells and allowed more proliferation compared to the control. Conclusion: One of the criteria in the selection of implants for orthopedic surgery is that a good implant should not need removal and thus a second surgery. In the present study, a bioabsorbable implant was designed considering this criterion. The present study is the first step to prove the safety of this new design by in vitro toxicity and viability experiments.
dc.identifier.citationİşyar, M., Yılmaz, İ., Nusran, G., Güler, O., Yalçın, S. ve Mahiroğulları, M. (2015). Safety of bioabsorbable implants in vitro. BMC Surgery, 15, https://dx.doi.org/10.1186/s12893-015-0111-4
dc.identifier.doi10.1186/s12893-015-0111-4
dc.identifier.issn1471-2482
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1140
dc.identifier.urihttps://dx.doi.org/10.1186/s12893-015-0111-4
dc.identifier.volume15
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBioMed Central
dc.relation.ispartofBMC Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBioabsorbable Implant
dc.subjectOsteoblastic Activity
dc.subjectOsteocyte Proliferation
dc.subjectPoly(lactic-co-glycolic acids)
dc.titleSafety of bioabsorbable implants in vitro
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
isyar, mehmet-2015.pdf
Boyut:
2.03 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu