Second evaluation of the mesenteric tissue after ethanol fixation improved the total and metastatic number of lymph nodes in colorectal resections

Basit Öğe Kaydı
dc.authorid0000-0003-0128-6947
dc.contributor.authorÇakır, Aslı
dc.contributor.authorÇetinaslan Türkmen, İlknur
dc.contributor.authorÜnlü Akhan, Aslı
dc.contributor.authorAkkoç, Merve
dc.contributor.authorKorkmaz, Pınar
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:51Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000457714000007
dc.descriptionPubMed ID: 30706856
dc.description.abstractContext: There is a correlation between prognosis of the colorectal carcinomas and the number of retrieved and metastatic lymph nodes (LNs) from mesentery/mesorectal region. At least 12 LNs must be sampled for accurate evaluation of patients. A number of factors related to surgeon, pathologist, patient and disease could affect the total LN number. For maximizing LN yield, pathologist can use ancillary methods, as fat clearance and special solutions. Aims: This study investigates the effect of second evaluation after ethanol fixation on total and metastatic LN number and assesses factors that influence the dissected LN number. Materials and Methods: 177 colorectal resections were refixed with ethanol for a night, after standard LN sampling. Mesentery/mesorectal tissue was reevaluated for missed LNs. Results were statistically analyzed, P values <0.05 were considered significant. Results: Mean LN number increased from 26 to 30 (median: 20 to 25, P < 0.001) after ethanol fixation. Fourteen cases had additional metastatic LNs after reevaluation of the fat tissue and 5 of them upstaged. 22.5% (44/177) of the patients had <12 LNs before ethanol fixation and this decreased to 14.3% (26/177) after ethanol fixation. Resection type and length, tumor localization, size and histologic degree, pT and neoadjuvant therapy (P < 0.001) had an impact on the LN number (P = 0.034 for histologic degree, P = 0.02 for pT, P < 0.001 for others). Conclusions: Carrying out a second evaluation with ethanol fixation increased total and metastatic LN number and could lead upstage of pN. Ethanol fixation is cost-effective, easy accessible and applicable method; it may improve accuracy of LN assessment and staging, which are important for patients' outcome.
dc.identifier.citationÇakır, A., Çetinaslan Türkmen, İ., Ünlü Akhan, A., Akkoç, M. ve Korkmaz, P. (2019). Second evaluation of the mesenteric tissue after ethanol fixation improved the total and metastatic number of lymph nodes in colorectal resections. Indian Journal of Pathology and Microbiology, 62(1), 31-35. https://dx.doi.org/10.4103/IJPM.IJPM_128_18
dc.identifier.doi10.4103/IJPM.IJPM_128_18
dc.identifier.endpage35
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage31
dc.identifier.urihttps://dx.doi.org/10.4103/IJPM.IJPM_128_18
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1794
dc.identifier.volume62
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publicatıions
dc.relation.ispartofIndian Journal of Pathology and Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectColorectal Carcinoma
dc.subjectEthanol
dc.subjectFat Clearance
dc.subjectlymph Node
dc.subjectIymph Node Sampling
dc.titleSecond evaluation of the mesenteric tissue after ethanol fixation improved the total and metastatic number of lymph nodes in colorectal resections
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
cakir-asli(2019).pdf
Boyut:
851.82 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu