Effects of topically applied contractubex (R) on epidural fibrosis and axonal regeneration in injured rat sciatic nerve

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dc.authorid0000-0002-6983-8632
dc.contributor.authorOzay, Rafet
dc.contributor.authorKeskin, Emrah
dc.contributor.authorBalkan, Mehmet Serdar
dc.contributor.authorAktaş, Abit
dc.contributor.authorAktürk, Umut Doğu
dc.contributor.authorEsener, Osman Behzat Burak
dc.contributor.authorAktürk, Tülin
dc.contributor.authorHanalioğlu, Şahin
dc.contributor.authorAtabey, Cem
dc.contributor.authorŞekerci, Zeki
dc.date.accessioned2023-07-06T07:28:33Z
dc.date.available2023-07-06T07:28:33Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractAIM: To investigate the effects of Contractubex (R) (Cx) on peripheral nerve regeneration and scar formation. MATERIAL and METHODS: A surgical procedure involving sciatic nerve incision in 24 adult male Sprague-Dawley rats followed by epineural suturing was performed. In weeks 4 and 12 following surgery, macroscopic, histological, functional, and electromyographic examinations of the sciatic nerve were conducted. RESULTS: No significant difference was found between the Cx group and the control group in terms of sciatic function index (SFI) and distal latency results at week 4 (p>0.05). However, significant improvements in the Cx group were observed in SFI amplitudes and nerve action potentials at week 12 (p<0.001 and p<0.001, respectively). Significant improvements were found in the amplitudes of nerve action potentials in the treatment group after weeks 4 and 12 (p<0.05 and p<0.001, respectively). Macroscopically and histopathologically, epidural fibrosis decreased (p<0.05 and p<0.001, respectively). For both measurement times, the treatment group had significantly higher numbers of axons (week 4, p<0.05; week 12, p<0.001), and the treatment group had better results regarding its axon area (weeks 4 and 12, p<0.001) and myelin thickness (weeks 4 and 12, p<0.05). CONCLUSION: Cx, which is applied topically in peripheral nerve injury, affects axonal regeneration and axonal maturation positively and reduces the functional loss.
dc.identifier.citationOzay, R., Keskin, E., Balkan, M. S., Aktaş, A., Aktürk, U. D., Esener, O. B. B. ... Şekerci, Z. (2023). Effects of topically applied contractubex (R) on epidural fibrosis and axonal regeneration in injured rat sciatic nerve. Turkish Neurosurgery, 33(3), 437-446. https://dx.doi.org/10.5137/1019-5149.JTN.40989-22.2
dc.identifier.doi10.5137/1019-5149.JTN.40989-22.2
dc.identifier.endpage446
dc.identifier.issn1019-5149
dc.identifier.issue3
dc.identifier.pmid37222011
dc.identifier.scopus2-s2.0-85159966637
dc.identifier.scopusqualityQ3
dc.identifier.startpage437
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.40989-22.2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11150
dc.identifier.volume33
dc.identifier.wos000996128800011en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞekerci, Zeki
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectContractubex
dc.subjectPeripheral Nerve
dc.subjectScarring
dc.subjectRats
dc.titleEffects of topically applied contractubex (R) on epidural fibrosis and axonal regeneration in injured rat sciatic nerve
dc.title.alternativeEffects of topically applied contractubex® on epidural fibrosis and axonal regeneration in injured rat sciatic nerve
dc.typeArticle

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