Patient-specific induced pluripotent stem cells for cardiac disease modeling

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dc.contributor.authorÇağavi, Esra
dc.contributor.authorAkgül Çağlar, Tuba
dc.contributor.authorHaider, Khawaja Husnain
dc.contributor.authorSöztekin, Gökçe İlayda
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:09Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:09Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000464646800009
dc.description.abstractReprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) via induction of pluripotency genes is one of the most influential scientific breakthroughs during the last decade. Behind this breakthrough is the capacity of iPSCs to self-renew and differentiate into derivatives of all the three germ layers, similar to human embryonic stem cells. Importantly, iPSCs can be generated using somatic cells from healthy donors or patients retaining the genetic and epigenetic make-up of the donor and can be used for regenerative applications without provoking immune rejection. Given their potential use in basic and translational research, iPSCs have become an attractive cell type to create "disease-on-a-dish" models to investigate disease phenotype in vitro, to assess drug response and evaluate cardiac toxicity for drug discovery, and to develop personalized cell therapy for various diseases. Among these diseases, inherited or acquired forms of cardiovascular diseases are the most common reason of mortality worldwide. Cardiac arrhythmias and channelopathies are a distinct group of disorders caused by abnormal ion homeostasis and action potential of cardiomyocytes, accounting for a large subset of hospitalization and sudden cardiac death. Pharmacological, catheter, or medical device implants and surgical approaches have been largely applied in the clinical perspective for symptomatic treatment and to improve the quality of life for patients with arrhythmias and other heart diseases. Recently, stem-cell-based regenerative approaches have been vigorously assessed in clinical trials, and novel stem-cell-based treatments are being evaluated for their potential use to provide lasting recovery. In this book chapter, we focus on the recent progress in the application of iPSC-related research in selected channelopathies and cardiac arrhythmia modeling in vitro and their potential application in the clinical perspective.
dc.identifier.citationÇağavi, E., Akgül Çağlar, T., Haider, K. H. ve Söztekin, G. İ. (2019). Patient-specific induced pluripotent stem cells for cardiac disease modeling. Stem Cells - From Hype To Real Hope, 146-172. https://dx.doi.org/10.1515/9783110587043-008
dc.identifier.doi10.1515/9783110587043-008
dc.identifier.endpage172
dc.identifier.isbn9783110587043
dc.identifier.isbn9783110586787
dc.identifier.startpage146
dc.identifier.urihttps://dx.doi.org/10.1515/9783110587043-008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3814
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWalter de Gruyter GMBH
dc.relation.ispartofStem Cells - From Hype To Real Hopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAction Potential
dc.subjectCardiac
dc.subjectCardiomyocytes
dc.subjectChannelopathy
dc.subjectElectrophysiology
dc.subjectHeart
dc.subjectiPSCs
dc.subjectModels
dc.titlePatient-specific induced pluripotent stem cells for cardiac disease modeling
dc.typeArticle

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