Oxidative stress and foxo-1 relationship in stage iii periodontitis

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dc.authorid0000-0001-7986-7085
dc.contributor.authorGürbüz, Elif Selin
dc.contributor.authorGüney, Zeliha
dc.contributor.authorKurgan, Şivge
dc.contributor.authorBalcı, Nur
dc.contributor.authorSerdar, Muhittin Abdulkadir
dc.contributor.authorGünhan, Meral
dc.date.accessioned2024-05-24T12:53:23Z
dc.date.available2024-05-24T12:53:23Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjectives: 8-Hydroxideoxyguanosine (8-OHdG) is a marker of oxidative stress, and Forkhead Box-O1 (FOXO1) is a transcription factor and signaling integrator in cell and tissue homeostasis. This study aims to determine FOXO1 and 8-OHdG levels in serum and saliva samples of periodontitis patients and to evaluate their relationship with clinical periodontal parameters. Materials and Methods: Twenty healthy individuals, twenty generalized Stage III Grade B periodontitis patients, and nineteen generalized Stage III Grade C periodontitis patients were included in the study. Clinical periodontal parameters (plaque index (PI), probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL)) were recorded. Salivary and serum 8-OHdG and FOX-O1 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: Clinical periodontal parameters showed a statistically significant increase in periodontitis groups compared to the control group (p < 0.05). 8-OHdG salivary levels were significantly higher in both periodontitis groups compared to the control group. The salivary FOXO1 levels were significantly lower in both periodontitis groups compared to the control group. Salivary FOXO1 level had a low-grade negative correlation with BOP and salivary 8-OHdG level. Conclusions: While reactive oxygen species increase in periodontal inflammation, low expression of FOXO1, an important transcription factor for antioxidant enzymes, supports that this molecule plays a vital role in tissue destruction, and FOXO1 can be seen as a potential immune modulator. Clinical relevance: The role of FOXO1 in supporting antioxidant defense may suggest that FOXO1 is a candidate target for periodontitis treatment.
dc.identifier.citationGürbüz, E. S., Güney, Z., Kurgan, Ş., Balcı, N., Serdar, M. A. ve Günhan, M. (2024). Oxidative stress and foxo-1 relationship in stage iii periodontitis. Clinical Oral Investigations, 28(5). http://dx.doi.org/10.1007/s00784-024-05670-x
dc.identifier.doi10.1007/s00784-024-05670-x
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue5
dc.identifier.pmid38658396
dc.identifier.scopus2-s2.0-85191307985
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1007/s00784-024-05670-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12502
dc.identifier.volume28
dc.identifier.wos001207774500001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalcı, Nur
dc.language.isoen
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject(MeSH): Periodontitis
dc.subject8-Hidroksideoksiguanozin (8-OHdG)
dc.subjectForkhead Box-O1 (FOXO1)
dc.subjectOxidative Stress
dc.titleOxidative stress and foxo-1 relationship in stage iii periodontitis
dc.typeArticle

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