The association of hla-drb1 alleles and mbl2 gene variant in pediatric acute lymphoblastic leukemia patients

Basit Öğe Kaydı
dc.contributor.authorOğuz, Rüştü
dc.contributor.authorŞentürk Çiftçi, Hayriye
dc.contributor.authorGökçe, Müge
dc.contributor.authorÖğret, Yeliz
dc.contributor.authorKaradeniz, Sedat
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorAydın, Filiz
dc.date.accessioned2025-07-28T10:07:45Z
dc.date.available2025-07-28T10:07:45Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractIntroduction: Epidemiologic studies on pediatric acute lymphoblastic leukemias (ALL) have been conducted to evaluate the possible risk factors including genetic, infectious and environmental factors with the objective of idenfying the etiology. Mannose-binding lectin 2 (MBL2) plays an important role in first-line immunedefense.HLADRB1 alleles play a role in presentation of peptides to T cells and in activation of the adaptive immune response. Objective: In our study, we aimed to investigate both the MBL2 gene variant and HLA-DRB1 alleles in pediatric ALL patients. Materials: In this study, 86 high-risk ALL patients and 100 controls were included. Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (PCR-RFLP) and PCRsequence specific primer (SSP) methods were used for detection of polymorphism of the MBL2andHLA-DRB1alleles, respectively. Results: The frequency of the MBL2 AB genotype was lower in female ALL patients, compared to male ALL patients (p = 0.034). An association was found between the MBL2 BB genotype and DRB1*07 andamongpatientswith theMBL2BBgenotype; thosewhoalsocarried the DRB1*07 and *04 alleles were significantly higher than those without the DRB1*07 and*04 alleles. (p = 0.048, p = 0.022, respectively). Conclusion: This is the first study suggesting that the MBL2 BB genotype in association with the DRB1*07 or co-inheritance of the HLA-DRB1*04 and HLA DRB1*07 may have an impact ontheetiopathogenesis of the disease.
dc.identifier.citationOğuz, R., Şentürk Çiftçi, H., Gökçe, M., Öğret, Y., Karadeniz, S., Özdilli, K. ... Aydın, F. (2024). The association of hla-drb1 alleles and mbl2 gene variant in pediatric acute lymphoblastic leukemia patients. Hematology Transfusion and Cell Therapy, 46(4), 327-334. http://dx.doi.org/10.1016/j.htct.2023.02.002
dc.identifier.doi10.1016/j.htct.2023.02.002
dc.identifier.endpage334
dc.identifier.issn2531-1379
dc.identifier.issue4
dc.identifier.pmid37117150
dc.identifier.startpage327
dc.identifier.urihttp://dx.doi.org/10.1016/j.htct.2023.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13025
dc.identifier.volume46
dc.identifier.wosWOS:001317935900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdilli, Kürşat
dc.institutionauthorid0000-0002-7129-5024
dc.language.isoen
dc.relation.ispartofHematology Transfusion and Cell Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAcute Lymphoblastic Leukemia
dc.subjectMannose-Binding Lectin 2
dc.subjectHuman Leukocyte Antigen
dc.subjectPolymorphism
dc.subjectChildhood Leukemias
dc.titleThe association of hla-drb1 alleles and mbl2 gene variant in pediatric acute lymphoblastic leukemia patients
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Özdilli-Kürşat-2024.pdf
Boyut:
418.2 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu