Vaccines and autoimmunity—From side effects to ASIA syndrome

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dc.authorid0000-0002-4130-3978
dc.authorid0000-0002-7919-1326
dc.contributor.authorSeida, İsa
dc.contributor.authorSeida, Ravend
dc.contributor.authorElsalti, Abdulrahman
dc.contributor.authorMahroum, Naim
dc.date.accessioned2023-03-10T11:37:44Z
dc.date.available2023-03-10T11:37:44Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractSince vaccines are in fact manufactured chemical compounds such as drugs, the appearance of side effects following their use is not surprising. Similarly, as the main goal of vaccines is to stimulate the immune system bringing out the production of protective antibodies, autoimmune-related side effects as a consequence of increased immune activity do not seem irrational. Fortunately, the rate of such side effects is low; however, the importance of reporting adverse events following vaccinations, understanding the mechanisms behind their appearance, making early diagnosis, and appropriate treatment cannot be overemphasized. In fact, autoimmune-related side effects of vaccines, particularly those based on adjuvants, were reported long before the introduction of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Nevertheless, ASIA gathered and united the side effects of vaccines under one title, a step which helped organize the research and call for better immune stimulators than adjuvants. New technologies and methods of making vaccines were clearly noticed during the pandemic of COVID-19 after the introduction of mRNA-based vaccines. In our current paper, we introduce the notion of side effects to vaccines, particularly those of autoimmune nature, the mechanisms of ASIA, and the main vaccines linked with the syndrome including the recent COVID-19 vaccines. The transition from side effects to ASIA is the main idea behind our work.
dc.identifier.citationSeida, İ., Seida, R., Elsalti, A. ve Mahroum, N. (2023). Vaccines and autoimmunity—From side effects to ASIA syndrome. Medicina (Lithuania), 59(2). https://dx.doi.org/10.3390/medicina59020364
dc.identifier.doi10.3390/medicina59020364
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue2
dc.identifier.pmid36837564
dc.identifier.scopus2-s2.0-85148853686
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.3390/medicina59020364
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10610
dc.identifier.volume59
dc.identifier.wos000940588100001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSeida, İsa
dc.institutionauthorSeida, Ravend
dc.institutionauthorElsalti, Abdulrahman
dc.institutionauthorMahroum, Naim
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofMedicina (Lithuania)en_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectASIA
dc.subjectAdjuvant
dc.subjectHepatitis B Vaccine
dc.subjectInfluenza Vaccine
dc.subjectCOVID-19
dc.titleVaccines and autoimmunity—From side effects to ASIA syndrome
dc.typeReview Article

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