Investigation of 3D-printed chitosan-xanthan gum patches

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dc.contributor.authorAltan, Eray
dc.contributor.authorTürker, Nurgül
dc.contributor.authorHindy, Osama Ali
dc.contributor.authorDirican, Zeynep
dc.contributor.authorBingöl Özakpınar, Özlem
dc.contributor.authorUzuner Demir, Ayşegül
dc.contributor.authorKalaskar, Deepak
dc.contributor.authorThakur, Sourbh
dc.contributor.authorGündüz, Oğuzhan
dc.date.accessioned2022-06-13T07:15:44Z
dc.date.available2022-06-13T07:15:44Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractIn this study, using a new polymer combination of Chitosan(CH)/Xanthan Gum(XG) has been exhibited for wound dressing implementation by the 3D-Printing method, which was fabricated due to its biocompatible, biodegradable, improved mechanical strength, low degradation rate, and hydrophilic nature to develop cell-mimicking, cell adhesion, proliferation, and differentiation. Different concentrations of XG were added to the CH solution as 0.25, 0.50, 0.75, 1, and 2 wt% respectively in the formic acid/distilled water (1.5:8.5) solution and rheologically characterized to evaluate their printability. The results demonstrated that high mechanical strength, hydrophilic properties, and slow degradation rate were observed with the presence and increment of XG concentration within the 3D-Printed patches. Moreover, in vitro cell culture research was conducted by seeding NIH 3T3 fibroblast cells on the patches, proving the cell proliferation rate, viability, and adhesion. Finally, 1% XG and 4% CH containing 3D-Printed patches were great potential for wound dressing applications.
dc.identifier.citationAltan, E., Türker, N., Hindy, O. A., Dirican, Z., Bingöl Özakpınar, Ö., Uzuner Demir, A. ... Gündüz, O. (2022). Investigation of 3D-printed chitosan-xanthan gum patches. International Journal of Biological Macromolecules, 213, 259-267. https://doi.org/10.1016/j.ijbiomac.2022.05.158
dc.identifier.doi10.1016/j.ijbiomac.2022.05.158
dc.identifier.endpage267
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid35649439
dc.identifier.scopus2-s2.0-85131137481
dc.identifier.scopusqualityQ1
dc.identifier.startpage259
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2022.05.158
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9518
dc.identifier.volume213
dc.identifier.wos000810262800007en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHindy, Osama Ali
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject3D Printing
dc.subjectBiomaterials
dc.subjectOptimisation
dc.subjectWound Dressing
dc.titleInvestigation of 3D-printed chitosan-xanthan gum patches
dc.typeArticle

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