The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach

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dc.authorid0000-0002-1289-4641
dc.authorid0000-0003-4292-5717
dc.authorid0000-0001-7566-1063
dc.contributor.authorSarıcaoğlu, Mevhibe
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorToprak, Güven
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2021-11-03T08:55:04Z
dc.date.available2021-11-03T08:55:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractIntroduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA would have beneficial effects on motor and behavioural outcomes in freezing of gait. To test this hypothesis, we examined the left pre-SMA stimulating effect of repetitive Transcranial Magnetic Stimulation (rTMS) on motor, cognitive and behavioural parameters in Parkinson's patients with FOG. Method: The study included 20 Parkinson's patients with FOG (3 females, 17 males) who received the left Pre-SMA rTMS procedure. The clinical assessments were performed on all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions. Results & discussion: We found significant improvements in motor, cognitive and behavioural symptoms (p<0.05). The main finding of our study is that Pre-SMA is an attractive stimulation area leading to critical improvement of symptoms of Parkinson' s patients with FOG. Conclusion: The high-frequency rTMS stimulation over the left preSMA has a restorative effect on the motor, cognitive and behavioural symptoms of Parkinson' s patients with FOG.
dc.identifier.citationSarıcaoğlu, M., Hanoğlu, L., Toprak, G., Helvacı Yılmaz, N. ve Yuluğ, B. (2022). The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach. Endocrine, Metabolic & Immune Disorders - Drug Targets, 22(5), 518-524. https://dx.doi.org/10.2174/1871530321666211014170107
dc.identifier.doi10.2174/1871530321666211014170107
dc.identifier.endpage524
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue5
dc.identifier.pmid34649492
dc.identifier.scopus2-s2.0-85133103273
dc.identifier.scopusqualityQ3
dc.identifier.startpage518
dc.identifier.urihttps://dx.doi.org/10.2174/1871530321666211014170107
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8553
dc.identifier.volume22
dc.identifier.wos000887892500007en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofEndocrine, Metabolic & Immune Disorders - Drug Targetsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBehavioural Symptoms
dc.subjectCognitive Symptoms
dc.subjectFreezing of Gait
dc.subjectMotor Symptoms
dc.subjectParkinson’s Disease
dc.subjectPresupplementary Area
dc.subjectRepetitive Transcranial Magnetic Stimulation
dc.titleThe multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach
dc.typeArticle

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