Outcomes of high-grade gastrointestinal graft-versus-host disease posthematopoietic stem cell transplantation in children

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dc.authorid0000-0002-1407-2334
dc.contributor.authorUygun, Vedat
dc.contributor.authorKocacık Uygun, Dilara Fatma
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorIrmak Öztürkmen, Seda
dc.contributor.authorKarasu, Gülsün
dc.contributor.authorHazar, Volkan
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:45Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:45Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000388566200044
dc.descriptionPubMed ID: 27858879
dc.description.abstractWe explored the clinical course of acute high-grade gastrointestinal graft-versus-host disease in children in a single center. This was a retrospective analysis of 28 pediatric patients who presented with a clinical diagnosis of stage III and IV acute graft-versus-host disease (aGVHD) of the gastrointestinal system (GIS). Generally, skin involvement was the initial manifestation of aGVHD that began in the first 3 weeks of hematopoietic stem cell transplantation (HSCT); on the other hand, GIS involvement predominated after the second week of HSCT. Reported adult data show a survival rate of only 25%; however, our study showed more favorable outcomes in children with a survival rate of 55%. We monitored levels of albumin and immunoglobulin G and observed low levels overall during treatment of unresponsive patients, although only albumin levels were shown to be significantly different. We observed a significant increase in mortality with the use of antithymocyte globulin in GIS aGVHD, although antithymocyte globulin used for graft-versus-host disease prophylaxis had no demonstrable effect on GIS aGVHD mortality. Whether the significantly lower GIS aGVHD mortality among the children recruited in our study than among their historical adult counterparts is a primary result of the specific attributes of the pediatric GIS, or whether it originated from HSCT kinetics remains to be determined by future studies.
dc.identifier.citationUygun, V., Kocacık Uygun, D. F., Daloğlu, H., Irmak Öztürkmen, S., Karasu, G., Hazar, V. ... Yeşilipek, A. (2016). Outcomes of high-grade gastrointestinal graft-versus-host disease posthematopoietic stem cell transplantation in children. Medicine, 95(44). https://dx.doi.org/10.1097/MD.0000000000005242
dc.identifier.doi10.1097/MD.0000000000005242
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue44
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1097/MD.0000000000005242
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3431
dc.identifier.volume95
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChildren
dc.subjectGastrointestinal Graft-Versus-Host Disease
dc.subjectHematopoietic Stem Cell Transplantation
dc.titleOutcomes of high-grade gastrointestinal graft-versus-host disease posthematopoietic stem cell transplantation in children
dc.typeArticle

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