Preclinical evaluation of scorzonera sp root extracts and major compounds against acute hepatotoxicity induced by carbon tetrachloride

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dc.authorid0000-0002-8084-7855
dc.authorid0000-0002-7059-1884
dc.authorid0000-0002-0675-1839
dc.authorid0000-0002-9354-0000
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorKeskin, İlknur
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorSakul, Ayşe Arzu
dc.contributor.authorİşcan, Gülçin Saltan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:24Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:24Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000419284200007
dc.description.abstractEvaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana roots, methanol-water (80:20) extracts together with chlorogenic acid, scorzotomentosin-4'-O-beta-glucoside, hydrangenol-8-O-beta-glucoside as major compounds isolated from S. latifolia roots were tested for their hepatoprotective activities. Sprague Dawley rats were used for experiment and hepatotoxicity was induced by carbon tetrachloride. Aspartate aminotransferase and alanine aminotransferase levels were measured and all results were confirmed by histopathological examination. Plasma aspartate aminotransferase and alanine aminotransferase levels of examined groups were not significant when compared to carbon tetrachloride-treated groups. However histopathological results have revealed that all tested groups have less damage when compared to carbon tetrachloride group except scorzotomentosin-4'-O-beta-glucoside and hydrangenol-8-O-beta-glucoside groups. Scorzonera species displayed moderate hepatoprotective activities against carbon tetrachloride induced acute toxicity. Chlorogenic acid, among tested compounds exhibited higher activity than all tested Scorzonera species as well as other isolated compounds. Therefore chlorogenic acid could be suggested as responsible compound.
dc.identifier.citationÖzbek, H., Bahadır Acıkara, Ö., Keskin, İ., Kırmızı, N. İ., Yiğitbaşı, T., Sakul, A. A. ... İşcan, G. S. (2017). Preclinical evaluation of scorzonera sp root extracts and major compounds against acute hepatotoxicity induced by carbon tetrachloride. Indian Journal of Pharmaceutical Sciences, 79(5), 715-723. https://dx.doi.org/10.4172/pharmaceutical-sciences.1000284
dc.identifier.doi10.4172/pharmaceutical-sciences.1000284
dc.identifier.endpage723
dc.identifier.issn0250-474X
dc.identifier.issn1998-3743
dc.identifier.issue5
dc.identifier.startpage715
dc.identifier.urihttps://dx.doi.org/10.4172/pharmaceutical-sciences.1000284
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2692
dc.identifier.volume79
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectScorzonera Sp.
dc.subjectHepatoprotective Effect
dc.subjectCarbon Tetrachloride
dc.subjectChlorogenic Acid
dc.titlePreclinical evaluation of scorzonera sp root extracts and major compounds against acute hepatotoxicity induced by carbon tetrachloride
dc.typeArticle

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