The effect of PEGylation components on drug release behavior of targeted reduced graphene oxide based drug delivery system

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dc.authorid0000-0002-4634-3864
dc.authorid0009-0005-1551-0905
dc.authorid0000-0003-2776-5807
dc.contributor.authorBaşavcı, Ezgi
dc.contributor.authorDemirel, Erhan
dc.contributor.authorElhassan, Mohamad
dc.contributor.authorYüksel Durmaz, Yasemin
dc.date.accessioned2024-06-28T06:35:38Z
dc.date.available2024-06-28T06:35:38Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractReduced graphene oxide (rGO) is a restored, defect-free version of graphene oxide (GO) with regained graphene-like properties but encounters challenges in biomedical applications due to its low solubility. Especially for drug release applications, rGO's stronger ?-? interaction of rGO compared to GO leads to low release, often demanding novel approaches for enhancement. The recently developed PEGylation method utilizes a copolymer with tunable PEG chain length and density for the PEGylation of GO simultaneously reduced to rGO, resulting in water-dispersible and biocompatible rGO-based nanoplatforms. This copolymer integrates functional monomers and enhances treatment options. Herein, we investigated how these PEGylation components and their incorporation order impact rGO's drug release behavior. A series of copolymers, (P(PEGMA-co-AzPMA-co-MMA-co-PMA), with different PEG brushes and azide groups, were synthesized via atom transfer radical polymerization. We explored the impact of ionic azide groups on drug release by comparing the azide-containing and azide-capped copolymers. Moreover, copolymers containing 500 or 2000 Da PEG brushes were compared to assess their role as a coating layer or diffusion barrier on drug release. Doxorubicin, a hydrophobic anticancer agent, was loaded onto the rGO surface before or after peptide-based targeting agent (EPPT1) conjugation. The results showed that the drug release behavior of 500 or 2000 Da PEG brushes containing rGO surfaces are different due to the density of PEG coating which makes the effect of azide groups not always visible. Incorporating the targeting peptide before drug loading was found to be optimal. The pH-dependent release profiles revealed 49 % and 44 % release from the rGO surface for the shorter and longer PEG brushes, respectively. Tuning the PEGylation components may further influence the release behavior.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBITAK)en_US
dc.description.sponsorshipTurkish Academy of Scienceen_US
dc.identifier.citationBaşavcı, E., Demirel, E., Elhassan, M. ve Yüksel Durmaz, Y. (2024). The effect of PEGylation components on drug release behavior of targeted reduced graphene oxide based drug delivery system. European Polymer Journal, 215. http://dx.doi.org/10.1016/j.eurpolymj.2024.113211
dc.identifier.doi10.1016/j.eurpolymj.2024.113211
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85195863455
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.eurpolymj.2024.113211
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12664
dc.identifier.volume215
dc.identifier.wos001255519500001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBaşavcı, Ezgi
dc.institutionauthorDemirel, Erhan
dc.institutionauthorElhassan, Mohamad
dc.institutionauthorYüksel Durmaz, Yasemin
dc.language.isoen
dc.relation.ispartofEuropean Polymer Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiocompatible
dc.subjectDrug Release
dc.subjectGraphene Oxide
dc.subjectPEGylation
dc.subjectTargeting Drug Delivery System
dc.subject?-? interaction
dc.titleThe effect of PEGylation components on drug release behavior of targeted reduced graphene oxide based drug delivery system
dc.typeArticle

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