Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma

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dc.authorid0000-0002-2563-2149
dc.authorid0000-0001-9829-7268
dc.contributor.authorEliaçık, Mustafa
dc.contributor.authorErdur Karaman, Sevil
dc.contributor.authorAltıok Baltepe, İnci
dc.contributor.authorGülkılık, Gökhan
dc.contributor.authorAslan Anıl, Cemile
dc.contributor.authorKaya, Faruk
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:35Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000369596300007
dc.descriptionPubMed ID: 26853174
dc.description.abstractIn our study we aimed to evaluate the short-term effects of dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with pseudoexfoliative glaucoma (PXG). This prospective observational cross-sectional study enrolled 22 eyes of 22 newly-diagnosed patients with PXG in a single center. All of the patients received a fixed combination of dorzolamide/timolol. Besides routine ophthalmologic examination, the retrobulbar hemodynamic parameters in the ophthalmic artery, central retinal artery, and short posterior ciliary arteries were measured in all participants at baseline and the 3rd month using color Doppler imaging. The mean intraocular pressure (IOP) was 22.3 +/- 2.1 mmHg at baseline and reduced to 17.4 +/- 2.3 mmHg at the 3rd month (p < 0.05). None of the retrobulbar parameters, except peak systolic velocity and resistive index in temporal short posterior ciliary arteries, changed significantly on therapy with dorzolamide/timolol fixed combination when the results were analyzed at Month 3. The drug significantly decreased the peak systolic velocity (p = 0.044) and reduced the resistive index in 0.04 units, 95% confidence interval 0.03-0.05, (p < 0.001) in the temporal short posterior ciliary arteries. This study reports that the retrobulbar hemodynamics might be affected less than expected by dorzolamide/timolol fixed combination in patients with PXG although the reduction of IOP was statistically significant.
dc.identifier.citationEliaçık, M., Erdur Karaman, S., Altıok Baltepe, İ., Gülkılık, G., Aslan Anıl, C. ve Kaya, F. (2016). Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma. Kaohsiung Journal Of Medical Sciences, 32(1), 38-43. https://dx.doi.org/10.1016/j.kjms.2015.12.004
dc.identifier.doi10.1016/j.kjms.2015.12.004
dc.identifier.endpage43
dc.identifier.issn1607-551X
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage38
dc.identifier.urihttps://dx.doi.org/10.1016/j.kjms.2015.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3351
dc.identifier.volume32
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwan
dc.relation.ispartofKaohsiung Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectColor Doppler Imaging
dc.subjectDorzolamide-Timolol
dc.subjectGlaucoma
dc.subjectPseudoexfoliation
dc.subjectRetrobulbar Ocular Blood Flow
dc.titleEffects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma
dc.typeArticle

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