Influence of the gut microbiome on IgE and non-IgE-mediated food allergies

Basit Öğe Kaydı
dc.authorid0000-0003-1333-2648
dc.contributor.authorAktaş, Özge
dc.contributor.authorTurturice, Benjamin
dc.contributor.authorMetwally, AboBakr
dc.contributor.authorYazıcı, Duygu
dc.contributor.authorÖztürk, Ayşe Bilge
dc.contributor.authorUslu Kızılkan, Nuray
dc.contributor.authorKaya, A.
dc.contributor.authorArık Yılmaz, Ebru
dc.contributor.authorNacaroğlu, Tekin
dc.contributor.authorSackesen, Cansın
dc.contributor.authorPerkins, D. L.
dc.contributor.authorFinn, Patricia
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:22Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionCongress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- MAY 26-30, 2018 -- Munich, GERMANY
dc.descriptionWOS: 000441690400204
dc.description.abstractBackground: The prevalence of food allergy (FA) in children has been increasing in last decade. Recent studies show changes in gut microbiome with FA. However, whether gut microbiome may differ between IgE and non?IgE?mediated FA is not defined. The aim of this study is to examine the intestinal microbiome composition in infants with IgE and non?IgE?mediated FA and healthy infants. Method: Infants younger than 1?year?old, breastfed and diagnosed with FA by a physician were included in the study. DNA was isolated from stool samples of infants with non?IgE?mediated FA (n = 25) and IgE?mediated FA (n = 11) and healthy infants (n = 7). Whole genome shotgun sequencing was applied to identify the composition of microbial DNA (an average depth of 3.1 ± 0.8 million paired end reads and 0.9 ± 0.2 gigabase pairs). Results: There were compositional differences among 3 different groups. Shannon index was significantly higher in IgE?mediated FA compared to non?IgE?mediated FA group (Kruskal?Wallis test, P = 0.034). Even though ??diversity was similar, the Sparse Partial Least Square Discriminant Analysis (sPLS?DA) demonstrated that there were taxa?level differences among three groups. In species level, Veillonella parvula was in a significantly higher density in healthy infants compared to IgE and non?IgE?mediated FA groups. Rahnella aquatilis and Lactobacillus salivarius were significantly lower and Treponema succinifaciens significantly higher in IgE?mediated FA group compared to other groups. Additionally, Prevotella sp. oral taxon 299 was significantly lower in non?IgE?mediated FA group compared to others. Prevotella sp oral taxon 299 was related to mucus in stool whereas urticaria related species were Olsenall uli, Bactreoides thetaiotaomicron, Klebsiella variiocola, Rahnella aquatilis, Treponema succinfaciens, Ethanoligenens harbinenese. Conclusion: Analysis of microbiome differences in FA patients may aid in the understanding of the disease process. The present data suggest that there are compositional variations mostly in species? level among infants with FA and healthy ones. Our results suggest that the gut microbiome has a stronger relationship to IgE?mediated than non?IgE?mediated FA. Further functional analysis of the microbiome may help better understand the changes seen in the gut microbiome in FAs and improve our knowledge in the disease etiopathology.
dc.description.sponsorshipEuropean Academy of Allergy and Clinical Immunologyen_US
dc.identifier.citationAktaş, Ö., Turturice, B., Metwally, A., Yazıcı, D., Öztürk, A. B., Kızılkan, N. U. ... Finn, P. (2018). Influence of the gut microbiome on IgE and non-IgE-mediated food allergies. Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) içinde (116-117. ss.). Munich, Germany, May 26-30, 2018.
dc.identifier.endpage117
dc.identifier.issn0105-4538
dc.identifier.issn1398-9995
dc.identifier.issueSupplement: 105
dc.identifier.startpage116
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1963
dc.identifier.volume73
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCongress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIgE
dc.subjectNon?IgE?Mediated
dc.subjectFood Allergies
dc.titleInfluence of the gut microbiome on IgE and non-IgE-mediated food allergies
dc.typeConference Object

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Nacaroglu, Tekin-2018.pdf
Boyut:
229.9 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Bildiri Koleksiyonu