COVID-19 vaccination-related headache showed two different clusters in the long-term course: A prospective multicenter follow-up study (COVA-Head Study)

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dc.authorid0000-0002-4104-8508
dc.contributor.authorÇimen Atalar, Arife
dc.contributor.authorÖzdağ Acarlı, Ayşe Nur
dc.contributor.authorBaykan, Betül
dc.contributor.authorMartelletti, Paolo
dc.contributor.authorBolay, Hayrunnisa
dc.contributor.authorErtaş, Mustafa
dc.contributor.authorEkizoğlu, Esme
dc.contributor.authorÖzge, Aynur
dc.date.accessioned2023-10-16T10:48:19Z
dc.date.available2023-10-16T10:48:19Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackgroundAlthough acute headache following COVID-19 vaccination is widely acknowledged, the long-term progression of these headaches remains poorly understood. Our objective was to identify various phenotypes of prolonged or worsened headaches associated with COVID-19 vaccination and document any changes in these phenotypes over an extended period. Additionally, we aimed to document the diverse headache presentations among patients with pre-existing primary headaches.MethodsA multinational, prospective observational study was conducted to investigate prolonged or worsened headaches associated with COVID-19 vaccination. Questionnaires assessing COVID-19 vaccination-related headaches at three time points (initial visit, 3rd month follow-up, and 6th month follow-up) were developed for the study. Headache specialists/clinicians evaluated patients using these questionnaires in a prospective manner. Repeated K-means cluster analysis was performed to identify patient profiles with prolonged or worsened headaches related to COVID-19 vaccination.ResultsAmong the 174 patients included in the study, there was a female-to-male ratio of 128 (73.6%) to 46 (26.4%). The mean age of the patient group was 45.2 +/- 13.3 years, and 107 patients (61.5%) had a pre-existing history of primary headaches. Through the analysis, two major clusters were identified based on headache characteristics at each visit. During the first visit (n = 174), Cluster 1 primarily comprised patients with a history of primary headaches, frontal localization of pain, throbbing pain type, more severe headaches accompanied by symptoms such as nausea, phonophobia, photophobia, and osmophobia, and worsened by physical activity. In contrast, Cluster 2 consisted of patients with longer headache durations (over one month) and a stabbing/pressing quality of pain. Patients in Cluster 1 had a higher prevalence of migraine as the pre-existing primary headache disorder compared to Cluster 2 (90.48% vs. 68.18%, respectively; p = 0.005).ConclusionThe identification of two distinct phenotypes of prolonged or worsened headaches related to COVID-19 vaccination can provide valuable clinical insights. Having an awareness of the potential worsening of headaches following COVID-19 vaccination, particularly in patients with a primary headache disorder such as migraine, can help clinicians and headache experts anticipate and adjust their treatment strategies accordingly. This knowledge can aid in preplanning treatment modifications and optimize patient care.
dc.identifier.citationÇimen Atalar, A., Özdağ Acarlı, A. N., Baykan, B., Martelletti, P., Bolay, H., Ertaş, M. ... Özge, A. (2023). COVID-19 vaccination-related headache showed two different clusters in the long-term course: A prospective multicenter follow-up study (COVA-Head Study). Journal of Headache and Pain, 24(1). https://doi.org/10.1186/s10194-023-01665-3
dc.identifier.doi10.1186/s10194-023-01665-3
dc.identifier.issn1129-2369
dc.identifier.issn1129-2377
dc.identifier.issue1
dc.identifier.pmid37773092
dc.identifier.scopus2-s2.0-85173568334
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s10194-023-01665-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11589
dc.identifier.volume24
dc.identifier.wos001075386300001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPolat, Burcu
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJournal of Headache and Painen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCOVID
dc.subjectVaccination
dc.subjectLong-COVID
dc.subjectHeadache
dc.subjectPrimary Headache
dc.titleCOVID-19 vaccination-related headache showed two different clusters in the long-term course: A prospective multicenter follow-up study (COVA-Head Study)
dc.typeArticle

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