The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression

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dc.contributor.authorAkdağ, Mehmet Zülkif
dc.contributor.authorOğraş, Emrah
dc.contributor.authorDoğanyiğit, Züleyha
dc.contributor.authorAkyüz, Enes
dc.contributor.authorAkdağ, Mahmut Berat
dc.contributor.authorOkan, Aslı
dc.contributor.authorAkpolat, Veysi
dc.contributor.authorKüllü, İ?rem
dc.date.accessioned2024-01-31T12:55:21Z
dc.date.available2024-01-31T12:55:21Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoterapi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractThe aim of this study was to understand the expression of big potassium (BK, K(Ca)1.1) channels in epileptic seizures under magnetic field application. Forty Wistar albino adult male rats were divided into five groups (n = 8). First group rats were control group. Pentylenetetrazole (PTZ) administrated to second group rats to induce the seizures with 35 mg/kg intraperitoneally injection every two days. Levetiracetam (LEV) i.p. at a dose of 108 mg/kg was given to third group rats as positive control group (PC) before 20 minutes PTZ administration. Pulsed magnetic field with 1.5 mT was exposed to the fourth group rats for 3 hours a day for 1 month as magnetic field (MF) group. 1.5 mT pulsed magnetic field was exposed to the fifth group rats for 3 hours a day for 1 month in addition to PTZ administration (PTZ+MF). K(Ca)1.1 not changed in hippocampus of PTZ rats while increased in frontal cortex and pons for PTZ group but not changed with magnetic field exposure. K(Ca)1.1 increased in heart of PTZ animals and turned back to mean control values with magnetic field exposure. Suppressing the expected increase of c-fos protein expression in seizures with magnetic field application but not being able to change the K(Ca)1.1 expression shows that new studies can be done by increasing the frequency of 1.5 mT magnetic field.
dc.identifier.citationAkdağ, M. Z., Oğraş, E., Doğanyiğit, Z., Akyüz, E., Akdağ, M. B., Okan, A. ... Küllü, İ?. (2023). The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression. Electromagnetic Biology and Medicine, 42(2), 81-97. https://dx.doi.org/10.1080/15368378.2023.2247027
dc.identifier.doi10.1080/15368378.2023.2247027
dc.identifier.endpage97
dc.identifier.issn1536-8378
dc.identifier.issn1536-8386
dc.identifier.issue2
dc.identifier.pmid37598353
dc.identifier.scopus2-s2.0-85168368040
dc.identifier.scopusqualityQ3
dc.identifier.startpage81
dc.identifier.urihttps://dx.doi.org/10.1080/15368378.2023.2247027
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12229
dc.identifier.volume42
dc.identifier.wos001050567100001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkdağ, Mahmut Berat
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofElectromagnetic Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/221S563
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPTZ-Kindled Model
dc.subjectMagnetic Field
dc.subjectBK Channels
dc.subjectSeizure
dc.subjectC-fos
dc.titleThe increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression
dc.typeArticle

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