Anti-mullerian hormone levels increase after bariatric surgery in obese female patients with and without polycystic ovary syndrome

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dc.authorid0000-0002-8549-2643
dc.contributor.authorBüyükbaba, Mitat
dc.contributor.authorTurgut, Seda
dc.contributor.authorİlhan, Mahmut Muzaffer
dc.contributor.authorEkinci, İskender
dc.contributor.authorYaylım, İlhan
dc.contributor.authorZeybek, Şakir Ümit
dc.contributor.authorTuran, Saime
dc.contributor.authorTaşan, Ertuğrul
dc.contributor.authorKaraman, Özcan
dc.date.accessioned2022-03-25T07:14:19Z
dc.date.available2022-03-25T07:14:19Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThis study was aimed to investigate the effect of weight loss by bariatric surgery on the level of anti-Mullerian hormone (AMH) in morbidly obese female patients with or without polycystic ovary syndrome (PCOS). This prospective study includes 70 females, obese, and fertile patients of reproductive age. All patients were evaluated to determine the changes in weight, body mass index (BMI), serum AMH, and other biochemical parameters at the end of six months. The mean levels of the preop and postop AMH were 1.66 +/- 0.87 ng/ml and 5.99 +/- 1.39 ng/ml in the PCOS group; 1.35 +/- 0.76 ng/ml and 6.23 +/- 1.47 ng/ml in the non-PCOS group, respectively. The postop AMH levels were significantly higher than the preop levels for both groups (p<0.001). There were significant differences in the level of glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, total cholesterol, hemoglobin A1c, HOMA-IR, insulin between preop and postop 6th month. A negative correlation was found between postop AMH and body weight in all patients (r=-0.337, p=0.031). Postop AMH levels were negatively correlated with postop BMI levels in the non-PCOS patient group (r=-0.408, p=0.043). No significant difference was observed between the PCOS and non-PCOS groups in terms of all the parameters examined. In conclusion, our study suggests that the significantly increased AMH levels by losing weight with bariatric surgery in patients with morbid obesity with and without PCOS may indicate the improvement of fertilization potential. It could be considered when evaluating fertility in patients with morbid obesity.
dc.identifier.citationBüyükbaba, M., Turgut, S., İlhan, M. M., Ekinci, İ., Yaylım, İ., Zeybek, Ş. Ü. ... Karaman, Ö. (2022). Anti-mullerian hormone levels increase after bariatric surgery in obese female patients with and without polycystic ovary syndrome. Hormone and Metabolic Research, 54(3), 194-198. https://doi.org/10.1055/a-1756-4798
dc.identifier.doi10.1055/a-1756-4798
dc.identifier.endpage198
dc.identifier.issn0018-5043
dc.identifier.issn1439-4286
dc.identifier.issue3
dc.identifier.pmid35276745
dc.identifier.scopus2-s2.0-85126389834
dc.identifier.scopusqualityQ2
dc.identifier.startpage194
dc.identifier.urihttps://doi.org/10.1055/a-1756-4798
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9164
dc.identifier.volume54
dc.identifier.wos000767515100008en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİlhan, Mahmut Muzaffer
dc.language.isoen
dc.publisherGeorg Thieme Verlag KG
dc.relation.ispartofHormone and Metabolic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInfertility
dc.subjectPolycystic Ovary Syndrome
dc.subjectReproductive Functions
dc.subjectWeight Loss
dc.titleAnti-mullerian hormone levels increase after bariatric surgery in obese female patients with and without polycystic ovary syndrome
dc.typeArticle

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