Evaluation of the association of mucosa-associated invariant t (mait) cells with childhood asthma

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dc.contributor.authorEkşi, Meral
dc.contributor.authorBulut, Huri
dc.contributor.authorAkalın, Erdem
dc.contributor.authorUstabaş Kahraman, Feyza
dc.contributor.authorYazan, Hakan
dc.contributor.authorYazıcı, Mebrure
dc.contributor.authorÇakır, Erkan
dc.date.accessioned2025-12-10T08:56:34Z
dc.date.available2025-12-10T08:56:34Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/aim: Innate-like T lymphocytes are a recently defined group of T cells comprising mainly mucosa-associated invariant T (MAIT) cells. The relationship between MAIT cells and childhood asthma is controversial. In this study, we aimed to determine the role of MAIT cells in patients with allergic asthma (AA) and nonallergic asthma (NAA). This is the first study to compare the ratios of these cells in patients with AA and NAA. Materials and methods: The study included children aged 6–18 years with AA (n = 41) or NAA (n = 30) and healthy control subjects (n = 36). The control group consisted of children who presented to the outpatient clinic without chronic disease, malnutrition, or acute or chronic infection. The proportions of MAIT, TH17, MAIT-17, and Th17-17 cells were investigated by flow cytometry and compared among the AA, NAA, and control groups. Results: When the AA and NAA patient groups were compared, the mean MAIT cell ratio was significantly lower in NAA patients (median: 0.45, p < 0.05). MAIT cell ratios were also substantially lower in NAA patients compared to the control group (mean: 0.504, p < 0.05). TH17, MAIT-17, and TH17-17 cell values were not statistically significant among the groups. Conclusion: Our study found that MAIT cell ratios were lower in the NAA patient group compared to the control group and AA patients. It has been predicted that MAIT cell depletion may have a role in the development of NAA. Our study is the first on this subject in the literature and further studies are needed.
dc.description.sponsorshipBezmialem Vakıf University BAP Coordination Unit
dc.identifier.citationEkşi, M., Bulut, H., Akalın, E., Ustabaş Kahraman, F., Yazan, H., Yazıcı, M. ... Çakır, E. (2024). Evaluation of the association of mucosa-associated invariant t (mait) cells with childhood asthma. Turkish Journal of Medical Sciences, 54(6), 1265-1270. http://dx.doi.org/10.55730/1300-0144.5908
dc.identifier.doi10.55730/1300-0144.5908
dc.identifier.endpage1270
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid39734354
dc.identifier.scopus2-s2.0-85212296368
dc.identifier.scopusqualityQ2
dc.identifier.startpage1265
dc.identifier.urihttp://dx.doi.org/10.55730/1300-0144.5908
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13317
dc.identifier.volume54
dc.identifier.wosWOS:001429214400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUstabaş Kahraman, Feyza
dc.institutionauthorid0000-0003-3842-7723
dc.language.isoen
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAllergy
dc.subjectChildhood Asthma
dc.subjectInnate Cells
dc.subjectInterleukin 17
dc.subjectMucosa-Associated Invariant T Cells
dc.subjectT Helper 17 Cell
dc.titleEvaluation of the association of mucosa-associated invariant t (mait) cells with childhood asthma
dc.typeArticle

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