The p53/mirna axis in breast cancer

Basit Öğe Kaydı
dc.contributor.authorHosseini, Reza Shah
dc.contributor.authorNouri, Seyed Mohammad
dc.contributor.authorBansal, Pooja
dc.contributor.authorHjazi, Ahmed
dc.contributor.authorKaur, Harpreet
dc.contributor.authorKareem, Anaheed Hussein
dc.contributor.authorMahdavi, Parya
dc.date.accessioned2025-10-14T10:00:45Z
dc.date.available2025-10-14T10:00:45Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi
dc.description.abstractOne of the main health issues in the modern world is cancer, with breast cancer (BC) as one of the most common types of malignancies. Different environmental and genetic risk factors are involved in the development of BC. One of the primary genes implicated in cancer development is the p53 gene, which is also known as the “gatekeeper” gene. p53 is involved in cancer development by interacting with numerous pathways and signaling factors, including microRNAs (miRNAs). miRNAs are small noncoding RNA molecules that regulate gene expression by binding to the 3¢ untranslated region of target mRNAs, resulting in their translational inhibition or degradation. If the p53 gene is mutated or degraded, it can contribute to the risk of BC by disrupting the expression of miRNAs. Similarly, the disruption of miRNAs causes the negative regulation of p53. Therefore, the p53/miRNA axis is a crucial pathway in the progression or prevention of BC, and understanding the regulation and function of this pathway may contribute to the development of new therapeutic strategies to help treat BC.
dc.description.sponsorshipKermanshah University of Medical Sciences ; Shiraz University of Medical Science ; Golestan University of Medical Sciences
dc.identifier.citationHosseini, R. S., Nouri, S. M., Bansal, P., Hjazi, A., Kaur, H., Kareem, A. H. ... Mahdavi, P. (2024). The p53/mirna axis in breast cancer. DNA and Cell Biology, 43(11), 549-558. http://dx.doi.org/10.1089/dna.2024.0181
dc.identifier.doi10.1089/dna.2024.0181
dc.identifier.endpage558
dc.identifier.issn1044-5498
dc.identifier.issn1557-7430
dc.identifier.issue11
dc.identifier.pmid39423159
dc.identifier.scopus2-s2.0-85207371785
dc.identifier.scopusqualityQ2
dc.identifier.startpage549
dc.identifier.urihttp://dx.doi.org/10.1089/dna.2024.0181
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13101
dc.identifier.volume43
dc.identifier.wosWOS:001335072100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHosseini, Reza Shah
dc.language.isoen
dc.relation.ispartofDNA and Cell Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast Cancer
dc.subjectMirna
dc.subjectP53
dc.subjectSignaling Pathway
dc.titleThe p53/mirna axis in breast cancer
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu