Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acy1-2,3-dihydropyridones

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dc.authorid0000-0002-1423-0435
dc.contributor.authorGüzel, Mustafa
dc.contributor.authorWatts, Joshua
dc.contributor.authorMcGilvary, Matthew
dc.contributor.authorWright, Marcus
dc.contributor.authorKiren, Sezgin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:15Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:15Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000360510700004
dc.description.abstractWe describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N-acy1-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions.
dc.description.sponsorshipWinston Salem State University NSF HBCU-UP Program [0927905]en_US
dc.description.sponsorshipWe gratefully acknowledge Winston Salem State University NSF HBCU-UP Program (0927905) for financial help. Also, we would like to thank Prof. Mark E. Welker in the department of Chemistry at Wake Forest University for their contribution and providing access to their research facilities.en_US
dc.identifier.citationGüzel, M., Watts, J., McGilvary, M., Wright, M. ve Kiren, S. (2015). Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acy1-2,3-dihydropyridones. Tetrahedron Letters, 56(38), 5275-5277. https://dx.doi.org/10.1016/j.tetlet.2015.07.045
dc.identifier.doi10.1016/j.tetlet.2015.07.045
dc.identifier.endpage5277
dc.identifier.issn0040-4039
dc.identifier.issue38
dc.identifier.scopusqualityQ2
dc.identifier.startpage5275
dc.identifier.urihttps://dx.doi.org/10.1016/j.tetlet.2015.07.045
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3835
dc.identifier.volume56
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.ispartofTetrahedron Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSubstituted Pyridines
dc.subjectN-Acyl-2,3-Dihydropyridones
dc.subjectOxidative Aromatization
dc.subjectChloranil
dc.subject1,2-Nucleophilic Addition
dc.titleSynthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acy1-2,3-dihydropyridones
dc.typeArticle

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