Repeated atmospheric pressure alteration effect on the cochlea in rats: Experimental animal study

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dc.authorid0000-0002-3887-4569
dc.contributor.authorEroğlu, Sinan
dc.contributor.authorTuran Dizdar, Handan
dc.contributor.authorCevizci, Raşit
dc.contributor.authorCengiz, Abdurrahman Buğra
dc.contributor.authorÖğreden, Şahin
dc.contributor.authorBulut, Erdoğan
dc.contributor.authorİlgezdi, Savaş
dc.contributor.authorDilci, Alper
dc.contributor.authorÜstün, Selin
dc.contributor.authorŞirvancı, Serap
dc.contributor.authorKaya, Özlem Tuğçe
dc.contributor.authorBayazıt, Dilara
dc.contributor.authorÇakır, Burak Ömür
dc.contributor.authorOktay, Mehmet Faruk
dc.contributor.authorBayazıt, Yıldırım
dc.date.accessioned2021-10-01T08:49:49Z
dc.date.available2021-10-01T08:49:49Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Odyoloji Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: This study aimed to evaluate the effects of repeated pressure alterations on cochlear structures in rats in an attempt to understand indirectly the inner ear status of flight crew who are repeatedly exposed to pressure alterations. METHODS: There were 12 adult Wistar albino rats equally divided into 2 groups: Group 1 (controls) and Group 2 (study group). The animals in Group 2 were exposed to repeated pressure changes in a pressure cabin which is regulated by manometers. The animals in Group 1 were placed in the cabin without being exposed to pressure changes. Auditory brainstem response (ABR) testing was performed in all animals at the beginning and at the end of the study. After 12 wk the animals were sacrificed and their cochleas were investigated using scanning electron microscopy (SEM). RESULTS: In the study group, hearing decreases at 2 kHz, 4 kHz, 6 dB at 8 kHz, and 32 kHz were encountered at the end of 3 mo. On SEM evaluation of the control group, the outer hair cells (OHC) and stereocilia were normal throughout the cochlea. In the study group, there were irregularities in lateral surface connections and separations, collapse, and adhesions in the basal segment of the cochlea and partial loss of stereocilia throughout the cochlea. CONCLUSION: Repeated alterations in the atmospheric pressure can lead to damage in the inner ear with subtle or evident hearing loss. Frequent flyers like air workers may be at risk of inner ear damage, which may be considered an occupational health problem.
dc.identifier.citationEroğlu, S., Turan Dizdar, H., Cevizci, R., Cengiz, A. B., Öğreden, Ş., Bulut, E. ... Bayazıt, Y. (2021). Repeated atmospheric pressure alteration effect on the cochlea in rats: Experimental animal study. Aerospace Medicine and Human Performance, 92(7), 550-555. https://dx.doi.org/10.3357/AMHP.5732.2021
dc.identifier.doi10.3357/AMHP.5732.2021
dc.identifier.endpage555
dc.identifier.issn2375-6314
dc.identifier.issn2375-6322
dc.identifier.issue7
dc.identifier.scopusqualityQ3
dc.identifier.startpage550
dc.identifier.urihttps://dx.doi.org/10.3357/AMHP.5732.2021
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8342
dc.identifier.volume92
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAerospace Medical Association
dc.relation.ispartofAerospace Medicine and Human Performanceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAltitude
dc.subjectBarotrauma
dc.subjectFlight
dc.subjectInner Ear
dc.titleRepeated atmospheric pressure alteration effect on the cochlea in rats: Experimental animal study
dc.typeArticle

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