Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates

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dc.authorid0000-0002-2306-5937
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-9704-6173
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorÖzdemir Öktem, Ece
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorUygur, Abdullah Burak
dc.contributor.authorÖzşimşek, Ahmet
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2020-08-28T08:08:53Z
dc.date.available2020-08-28T08:08:53Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractIntroduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and headache patients after paracetamol treatment. Material and methods: The study group included 16 patients with tension-type headache, and 12 healthy age-and sex-matched controls. After a detailed neurological examination Positive and Negative Affect Schedule (PANAS) and Empathy for Pain Scale (EPS) were applied to all subjects. Next, 1000 mg paracetamol tablet was administered orally, after administration of paracetamol, EPS were repeated, and fMRI was performed to all subjects. Results: We have revealed increased empathy scores in the headache group after the paracetamol treatment which were associated with significant alterations in brain regions which play a critical role in the processing of empathy. Discussion: The observed neuroimaging and clinical difference between healthy and headache subjects could be related to the fact that pain perception in healthy subjects might differ in some aspects from the mechanisms of empathy in headache-experienced patients. Conclusion: To the best of our knowledge, this is the first study that evaluated the paracetamol treatment and neural networks' correlation with pain empathy in healthy and headache individuals.
dc.identifier.citationÇankaya, Ş., Özdemir Öktem, E., Saatçi, Ö., Velioğlu, H. A., Uygur, A. B., Özşimşek, A. ... Yuluğ, B. (2020). Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates. Journal of Clinical Neuroscience, 78, 215-221. https://dx.doi.org/10.1016/j.jocn.2020.04.053
dc.identifier.doi10.1016/j.jocn.2020.04.053
dc.identifier.endpage221
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.scopusqualityQ2
dc.identifier.startpage215
dc.identifier.urihttps://dx.doi.org/10.1016/j.jocn.2020.04.053
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5756
dc.identifier.volume78
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Ltd.
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectParacetamol
dc.subjectfMRI
dc.subjectPain Empathy
dc.titleParacetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
dc.typeArticle

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