Current radiological techniques used to evaluate unilateral partial ureteral obstruction: An experimental rabbit study

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dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorÇelebi, Süleyman
dc.contributor.authorKuzdan, Özgür
dc.contributor.authorKoçan, Hüseyin
dc.contributor.authorAyyıldız, Halil Suat
dc.contributor.authorBayrak, İlkay Koray
dc.contributor.authorBilgici, Meltem Ceyhan
dc.contributor.authorYapıcı, Oktay
dc.contributor.authorKefeli, Mehmet
dc.contributor.authorArıtürk, Ender
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:02Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:02Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Çocuk Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000356902100002
dc.descriptionPubMed ID: 25943266
dc.description.abstractThe aim of this study was to evaluate functional and prognostic benefits of Doppler ultrasonography (DU), diuretic renal scintigraphy (DRS), and magnetic resonance urography (MRU) during diagnosis and follow-up of ureteropelvic junction obstruction (UPJO) and to examine apoptosis rates caused by UPJO in an experimental rabbit model. Twenty-four rabbits were divided randomly into two groups. The left kidneys of 15 rabbits from the first group underwent Ulm-Miller surgery to create UPJO, whereas the left kidneys of nine rabbits from the second group underwent sham surgery. A pressure flow study (Whitaker's test) was done during postoperative week 6. Based on the Whitaker test, the DU, DRS, and MRU findings were compared. The number of apoptotic renal cells was counted after death. The Whitaker test run during postoperative week 6 revealed obstructions in 15 rabbits from group 1; the nine rabbits of the sham group had no obstructions. Sensitivity and specificity of DRS were 93.3 and 88.8 %, respectively, and those of MRU were 93.3 and 88.8 %, respectively. The postoperative mean RI values were significantly higher than the preoperative values, associated with sensitivity of 86.6 % and specificity of 77.5 % for detecting UPJO. DRS, MRU, and RI could not predict UPJO in one (8 %), one (8 %), and two (16 %) kidneys, respectively. Likelihood ratio (LR) was 8.4 for MRU and scintigraphy, while for RI, LR was 3.9. Pathology specimens revealed that all kidneys with UPJO underwent apoptosis, and the number of apoptotic cells was significantly higher on the UPJO-created side than on the contralateral and in the sham group (p < 0.05). No test predicted all apoptosis related to UPJO. The RI, DRS, and DMRU results correlated with the pressure flow results for detecting UPJO. No single radiological technique predicted all initial UPJO-created kidneys that concluded with apoptosis. Further studies are required to seek with better methods for diagnosing an obstruction or to define a combination of radiological techniques aiding in the management decision.
dc.identifier.citationYazıcı, M., Çelebi, S., Kuzdan, Ö., Koçan, H., Ayyıldız, H. S., Bayrak, İ. K. ... Arıtürk, E. (2015). Current radiological techniques used to evaluate unilateral partial ureteral obstruction: An experimental rabbit study. International Urology and Nephrology, 47(7), 1045-1050. https://dx.doi.org/10.1007/s11255-015-0998-9
dc.identifier.doi10.1007/s11255-015-0998-9
dc.identifier.endpage1050
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage1045
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-015-0998-9
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2882
dc.identifier.volume47
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectUreteropelvic Junction Obstruction
dc.subjectDoppler Ultrasonography
dc.subjectDiuretic renal scintigraphy
dc.subjectMagnetic Resonance Urography
dc.subjectWhitaker Test
dc.titleCurrent radiological techniques used to evaluate unilateral partial ureteral obstruction: An experimental rabbit study
dc.typeArticle

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