The utility of first trimester uterine artery Doppler, placental volume and PAPP-A levels alone and in combination to predict preeclampsia

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dc.contributor.authorYücel, Burak
dc.contributor.authorGedikbaşı, Ali
dc.contributor.authorDündar, Öznur
dc.contributor.authorOlgaç, Yusuf
dc.contributor.authorYıldırım, Do?ukan
dc.contributor.authorYıldırım, Gökhan Yetkin
dc.contributor.authorPolat, İbrahim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:39Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000390825400006
dc.descriptionPubMed ID: 27939466
dc.description.abstractIn this study, we aimed to evaluate the detection of pre-eclampsia (PE) by integrating uterine artery Doppler, placental volume, and pregnancy-associated plasma protein A (PAPP-A) levels in the first trimester. We prospectively recruited 602 women that underwent 11-13 weeks' aneuploidy screening. The mean pulsatility index (PI) of the uterine arteries and the placental volume were measured by ultrasonography. Measurement of PAPP-A levels has been performed at the same day' of ultrasonographic examinations. The 90th percentile of uterine artery PI and the 10th percentile of placental volume and PAPP-A levels were used as cut-offs. Uterine artery PI, placental volume, and PAPP-A levels had similar sensitivities in predicting PE (53.66%, 63.41%, and 70.73%, respectively). Use of the parameters in combination had better sensitivity. If one parameter was positive, the sensitivity was 92.68% with 85.20% specificity. If at least two parameters were positive, the sensitivity was 85.37% with 98.89% specificity. In conclusion, the combination of increased PI of uterine artery with low placental volume and low PAPP-A levels in the first trimester achieved better results than either test alone in the prediction of PE.
dc.identifier.citationYücel, B., Gedikbaşı, A., Dündar, Ö., Olgaç, Y., Yıldırım, D., Yıldırım, G. Y. ve Polat, İ. (2016). The utility of first trimester uterine artery Doppler, placental volume and PAPP-A levels alone and in combination to predict preeclampsia. Pregnancy Hypertension-An International Journal Of Womens Cardiovascular Health, 6(4), 269-273. https://dx.doi.org/10.1016/j.preghy.2016.04.007
dc.identifier.doi10.1016/j.preghy.2016.04.007
dc.identifier.endpage273
dc.identifier.issn2210-7789
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage269
dc.identifier.urihttps://dx.doi.org/10.1016/j.preghy.2016.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3700
dc.identifier.volume6
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPregnancy Hypertension-An International Journal Of Womens Cardiovascular Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPregnancy-Associated Plasma Protein A (PAPP-A)
dc.subjectPlacental Volume
dc.subjectPredict Preeclampsia
dc.titleThe utility of first trimester uterine artery Doppler, placental volume and PAPP-A levels alone and in combination to predict preeclampsia
dc.typeArticle

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