Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus

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dc.authorid0000-0002-2563-2149
dc.contributor.authorKırgız, Ahmet
dc.contributor.authorEliaçık, Mustafa
dc.contributor.authorYıldırım, Yusuf
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:31Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000469914500001
dc.descriptionPubMed ID: 31172016
dc.description.abstractBackground: To compare the outcomes of two different protocols of accelerated corneal crosslinking (CXL) on visual, corneal high order aberrations (HOA) and topographic parameters in patients with progressive keratoconus. Methods: In this prospective comparative study, sixty-six eyes of 66 patients with progressive keratoconus were divided into two groups; 37 eyes in Group 1 received 18 mWcm(2) for five minutes, and 29 eyes in Group 2 were treated with 9 mW/cm(2) for 10 min. The uncorrected distant visual acuity (UCVA), best-corrected distant visual acuity (BCVA), corneal HOAs and topography parameters were measured preoperatively and postoperatively at the end of 12 months. The data for the two groups were compared statistically. Results: The mean UCVA and BCVA were significantly improved at the postoperative 12 months compared with the preoperative values in both groups (P <0.05 for all). A significant improvement in corneal HOAs was observed in both groups (P <0.05 for all). The change in corneal coma value was significantly higher in Group 2 (P <0.05). The change in keratometric values K1, K2, AvgK and maximum keratometry (AKf) were significantly higher in Group 2 (P <0.05 for all). The regression model showed that the most important factor predicting the change in AKf was the type of CXL (beta =- 0.482, P= 0.005). Conclusions: Accelerated CXL using 10 min of UVA irradiance at 9 mWcm(2) showed better topographic improvements and coma values than five minutes of UVA irradiance at 18 mW/cm(2) independent of keratoconus severity.
dc.identifier.citationKırgız, A., Eliaçık, M. ve Yıldırım, Y. (2019). Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus. Eye and Vision, 6. https://dx.doi.org/10.1186/s40662-019-0141-6
dc.identifier.doi10.1186/s40662-019-0141-6
dc.identifier.issn2326-0254
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://dx.doi.org/10.1186/s40662-019-0141-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1620
dc.identifier.volume6
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofEye and Visionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAccelerated Crosslinking
dc.subjectCorneal Collagen CXL
dc.subjectHigh Order Aberrations
dc.subjectKeratoconus
dc.subjectTopography
dc.titleDifferent accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus
dc.typeArticle

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